. . "2013-03-26+01:00"^^ . . "NT12130" . "P\u0159edkl\u00E1dan\u00FD projekt se zab\u00FDv\u00E1 extramedul\u00E1rn\u00EDm relapsem (EM) u pacient\u016F s mnoho\u010Detn\u00FDm myelomem. V sou\u010Dasnosti jsou pou\u017E\u00EDv\u00E1ny nov\u00E9 efektivn\u00ED l\u00E9ky, kter\u00E9 ovliv\u0148uj\u00ED v\u00FDskyt tohoto agresivn\u00EDho relapsu. Na\u0161e studie se zam\u011B\u0159\u00ED na charakterizaci plasmocyt\u016F jak z d\u0159en\u011B, tak z m\u011Bkkotk\u00E1\u0148ov\u00FDch lo\u017Eisek cytogenetick\u00FDmi a molekul\u00E1rn\u011B biologick\u00FDmi metodami. Bude provedena prospektivn\u00ED anal\u00FDza v\u00FDskytu EM u r\u016Fzn\u00FDch skupin pacient\u016F a bude navr\u017Eena zm\u011Bna l\u00E9\u010Debn\u00E9ho protokolu." . "This proposed project focuses on extramedullary relapse (EM) in patients with multiple myeloma. Currently, new effective drugs are used that seem to influence the occurence of this aggressive relapse. Our study will aim at characterization of plasmocytes from marrow as well as soft tissue lesions by cytogenetic and molecular biological methods. Retrospective analysis of EM occurence will be performed in various groups of patents and a change in the treatment protocol will be proposed."@en . . "Multiple myeloma" . . . "Complex analysis of importance and pathogenesis of extramedullary relapse in patients with multiple myeloma"@en . "38"^^ . "Komplexn\u00ED anal\u00FDza v\u00FDznamu a patogeneze extramedul\u00E1rn\u00EDho relapsu u pacient\u016F s\u00A0mnoho\u010Detn\u00FDm myelomem" . " chromosomal abnormalities" . "http://www.isvav.cz/projectDetail.do?rowId=NT12130"^^ . "38"^^ . . . "1"^^ . " extramedullary relapse" . . "0"^^ . "2014-12-31+01:00"^^ . . "0"^^ . . . "2011-06-01+02:00"^^ . . " flowcytometry" . "2015-01-22+01:00"^^ . . . . . "Multiple myeloma; extramedullary relapse; chromosomal abnormalities; flowcytometry; treatment optimalization"@en .