"2010-09-01+02:00"^^ . . " periodontitis" . " microbiology" . "NT11405" . "Mikrobiologick\u00E9 a genetick\u00E9 determinanty rozvoje a progrese parodontitidy u diabetik\u016F 1. a 2. typu a jejich recipro\u010Dn\u00ED vztah ke kompenzaci diabetu" . "2015-12-31+01:00"^^ . "2015-01-22+01:00"^^ . "diabetes mellitus; periodontitis; genetics; microbiology; dental plaque; diagnostics; prediction"@en . "Periodontitis is a chron. inflammatory disease of periodontal tissues initiated by dental plaque G- anaerobic bacteria with ~3-times higher risk in diabetics compared to non-diabetics, most likely due to a different immune reactivity to periodontal bacterial colonisation in hyperglycemia. Proposed project targets so far unsystematically mapped prevalence, type and severity of periodontal complications in diabetics in Czech population and its relationship with diabetes compensation. We will analyse periodontal status (clinical indexes + X-ray), microbial colonisation (DNA diagnostic kit for 7 common periopathogens), potential genetic risk factors (30\u201345 variants) and concentration of 7 soluble markers of inflammation and bone resorption (ELISA). Study will consist of case-control analysis (i.e. non- vs. diabetics, ~400 subjects) and prospective follow-up of diabetic cohort with the aim to predict event. progression of periodontitis by some of the markers ascertained or by their interactive effects."@en . " genetics" . . "http://www.isvav.cz/projectDetail.do?rowId=NT11405"^^ . . . . . "Microbiologic and genetic determinants of the onset and progression of periodontitis in type 1 and 2 diabetics and their reciprocal relationship to diabetes compensation"@en . " dental plaque" . . "14"^^ . . "14"^^ . "diabetes mellitus" . . . "0"^^ . "Parodontitida je chron. z\u00E1n\u011Btliv\u00E9 posti\u017Een\u00ED parodontu iniciovan\u00E9 G- anaerobn\u00EDmi bakteriemi dent\u00E1ln\u00EDho plaku s cca 3-kr\u00E1t vy\u0161\u0161\u00EDm rizikem u diabetik\u016F ve srovn\u00E1n\u00ED s nediabetickou populac\u00ED, pravd\u011Bpodobn\u011B v d\u016Fsledku rozd\u00EDln\u00E9 imuno-/z\u00E1n\u011Btliv\u00E9 reaktivity na bakteri\u00E1ln\u00ED os\u00EDdlen\u00ED parodontu p\u0159i hyperglyk\u00E9mii. Navrhovan\u00FD projekt \u0159e\u0161\u00ED v \u010CR dosud nesystematicky zmapovanou problematiku prevalence, typu a z\u00E1va\u017Enosti parodont\u00E1ln\u00EDho posti\u017Een\u00ED u diabetik\u016F a jeho vztahu k z\u00E1kl. onemocn\u011Bn\u00ED. Hodl\u00E1me vy\u0161et\u0159it parodont\u00E1ln\u00ED status (klin. indexy + RTG), mikrobi\u00E1ln\u00ED kolonizaci parodontu (DNA diagnostick\u00FD kit pro 7 obvykl\u00FDch parodont. patogen\u016F), potenci\u00E1ln\u00ED genetick\u00E9 rizikov\u00E9 faktory (30\u201345 variant) a koncentrace 7 vybran\u00FDch solubiln\u00EDch marker\u016F z\u00E1n\u011Btu a kostn\u00ED resorpce (ELISA). Studie zahrnuje anal\u00FDzu\u201Ekontroly x p\u0159\u00EDpady\u201C (tj. ne- vs. diabetici, cca 400 osob) a prospektivn\u00ED sledov\u00E1n\u00ED diabetick\u00E9 kohorty s c\u00EDlem predikovat event. progresi parodontitidy n\u011Bkter\u00FDmi ze stanovovan\u00FDch marker\u016F nebo jejich p\u0159\u00EDp. interak\u010Dn\u00EDho efektu." . . . "1"^^ . . "1"^^ . . " diagnostics" . "2014-03-21+01:00"^^ . . . . .