"biomarkers; nosocomial infections; sepsis; intensive care"@en . " nosocomial infections" . "http://www.isvav.cz/projectDetail.do?rowId=NT11390"^^ . . . . . . . . . . . "2010-09-01+02:00"^^ . "biomarkers" . "NT11390" . "0"^^ . " sepsis" . "Nosocomial infections (NI) represent an important problem in intensive care setting, since NI are responsible for a worse outcome and also for higher financial costs caused by prolonged hospitalization and use of broad spectrum antibiotics. Higher susceptibility of patients to NI is due to the following factors: breach integrity of nature barriers by inserted catheters, reduced bowel motility, worse cleaning of the airways and deregulated immune responses. Early after the primary sepsis the systemic inflammation develops, which main purpose is to eliminate primary infection. However, early after the inflammatory stimulation the control anti-inflammatory mediators (i.e. , cortisol, IL-10) are produced. It can be speculated that these mediators can increase the susceptibility to NI and that their deregulation influences diagnostics of NI. Thus, this project is aimed at selection of mediators, which may serve as early diagnostic biomarkers of NI."@en . "2015-01-22+01:00"^^ . . . "1"^^ . . . "1"^^ . "Nozokomi\u00E1ln\u00ED infekce (NI) v intenzivn\u00ED p\u00E9\u010Di p\u0159edstavuj\u00ED z\u00E1va\u017En\u00FD probl\u00E9m, nebo\u0165 d\u00E1le zhor\u0161uje progn\u00F3zu pro p\u0159e\u017Eit\u00ED a sou\u010Dasn\u011B v\u00FDznamn\u011B zvy\u0161uje finan\u010Dn\u00ED n\u00E1klady n\u00E1 l\u00E9\u010Dbu, v nich\u017E se prom\u00EDtaj\u00ED p\u0159edev\u0161\u00EDm prodlou\u017Een\u00E1 hospitalizace a n\u00E1kladn\u00E1 antimikrobi\u00E1ln\u00ED terapie. Vy\u0161\u0161\u00ED vn\u00EDmavost kriticky nemocn\u00FDch je zp\u016Fsobena n\u011Bkolika faktory: poru\u0161en\u00EDm p\u0159irozen\u00FDch bari\u00E9r zaveden\u00FDmi kat\u00E9try, sn\u00ED\u017Eenou motilitou st\u0159eva, zhor\u0161en\u00FDm o\u010Di\u0161\u0165ov\u00E1n\u00EDm d\u00FDchac\u00EDch cest a v neposledn\u00ED \u0159ad\u011B dysregulac\u00ED imunitn\u00ED odpov\u011Bdi. \u010Casn\u011B prim\u00E1rn\u00ED t\u011B\u017Ek\u00E9 sepsi doch\u00E1z\u00ED k syst\u00E9mov\u00E9mu z\u00E1n\u011Btu, kter\u00FD slou\u017E\u00ED k eliminaci vyvol\u00E1vaj\u00EDc\u00ED infekce. Nicm\u00E9n\u011B, z\u00E1hy po z\u00E1n\u011Btliv\u00E9 stimulaci je tato tlumena medi\u00E1tory s protiz\u00E1n\u011Btliv\u00FDm \u00FA\u010Dinkem (nap\u0159. kortizol, IL-10). D\u00E1 se p\u0159edpokl\u00E1d\u00E1t, \u017Ee pr\u00E1v\u011B tyto protiz\u00E1n\u011Btliv\u00E9 medi\u00E1tory zvy\u0161uj\u00ED vn\u00EDmavost k NI a \u017Ee sou\u010Dasn\u011B tato dysregulace ovliv\u0148uje i diagnostiku NI. V projektu se proto zam\u011B\u0159\u00EDme na vytipov\u00E1n\u00ED vhodn\u00FDch medi\u00E1tor\u016F, kter\u00E9 by mohly slou\u017Eit jako biomarkery NI a mohly by tedy b\u00FDt vyu\u017Eity pro jej\u00ED \u010Dasnou diagnostiku." . "2014-08-31+02:00"^^ . . . "2013-03-26+01:00"^^ . "5"^^ . "New biomarkers for a rapid detection of nosocomial infection in intensive care"@en . "Nov\u00E9 biomarkery pro \u010Dasnou detekci nozokomi\u00E1ln\u00ED infekce v intenzivn\u00ED p\u00E9\u010Di" . . "5"^^ .