. "1"^^ . . . " lactate" . . "2013-03-26+01:00"^^ . . . "microdialysis" . "NT11371" . . . "2010-10-01+02:00"^^ . . "A total of 50 patients will be followed with the method of microdialysis. The study group will consist of polytraumatised patients with an acute blood loss, with no other concomitant serious internal disorders. The investigators will monitor parameters of the internal environment directly affecting the supply and consumption of oxygen, levels in plasma and the intercellular fluid examined with the method of microdialysis. The impact will be placed mainly upon changes which may occur following the administration of blood transfusions. We will monitor the moment when the consumption of oxygen becomes limited with the supply and when the organism needs to increase the oxygen transport capacity. We will try to determine what is more effective at this moment \u2013 whether to increase the cardiac output or the level of haemoglobin. The levels in serum and microanalytes will be recorded for the maximum period of five days in minimal intervals of 8 hours.Complications and the state will be also monitored."@en . "Metodou mikrodial\u00FDzy svalov\u00E9 tk\u00E1n\u011B bude sledov\u00E1no celkem 50 pacient\u016F. Do projektu budou za\u0159azeni polytraumatizovan\u00ED pacienti s akutn\u00ED krevn\u00ED ztr\u00E1tou bez p\u0159idru\u017Een\u00FDch z\u00E1va\u017En\u00FDch intern\u00EDch onemocn\u011Bn\u00ED. Budou sledov\u00E1ny parametry vnit\u0159n\u00EDho prost\u0159ed\u00ED ovliv\u0148uj\u00EDc\u00ED bezprost\u0159edn\u011B dod\u00E1vku a spot\u0159ebu kysl\u00EDku a to jak hodnoty plasmatick\u00E9, tak hladiny v mezibun\u011B\u010Dn\u00E9 tekutin\u011B vy\u0161et\u0159ovan\u00E9 metodou mikrodial\u00FDzy. D\u016Fraz bude kladen p\u0159edev\u0161\u00EDm na zm\u011Bny, kter\u00E9 nastanou po pod\u00E1n\u00ED krevn\u00EDch transfuz\u00ED. Budeme sledovat okam\u017Eik, kdy spot\u0159eba kysl\u00EDku bude limitov\u00E1na dod\u00E1vkou a kdy je pro organismus nutn\u00E9 zv\u00FD\u0161it p\u0159enosovou kapacitu pro kysl\u00EDk. Budeme zji\u0161\u0165ovat, co je v t\u00E9to situaci efektivn\u011Bj\u0161\u00ED, zdali zv\u00FD\u0161it srde\u010Dn\u00ED v\u00FDdej nebo hladinu hemoglobinu. S\u00E9rov\u00E9 hladiny a mikroanalyty budou zaznamen\u00E1vany maxim\u00E1ln\u011B po dobu 5 dn\u00ED v minim\u00E1ln\u011B 8 hodinov\u00FDch intervalech. Budou sledov\u00E1ny p\u0159\u00EDpadn\u00E9 komplikace l\u00E9\u010Dby a stav pacienta." . . . "http://www.isvav.cz/projectDetail.do?rowId=NT11371"^^ . " O2 delivery" . "0"^^ . "microdialysis; hemoglobin; O2 delivery; lactate; transfusion trigger, hemorhagi"@en . . "Metabolic response of organism in polytrauma patients"@en . " transfusion trigger" . . . . " hemoglobin" . "2015-01-22+01:00"^^ . "2014-12-31+01:00"^^ . "1"^^ . . "Metabolick\u00E1 odezva organismu u polytraumat" . "1"^^ . "0"^^ . .