"0"^^ . "C\u00EDlem projektu je testovat prediktivn\u00ED v\u00FDznam mutac\u00ED genu ATM a polymorfismu proteinu TGF\u00DF na riziko pozdn\u00EDch postradia\u010Dn\u00EDch komplikac\u00ED u pacientek l\u00E9\u010Den\u00FDch radik\u00E1ln\u00ED chemoradioterapi\u00ED pro lok\u00E1ln\u011B pokro\u010Dil\u00FD karcinom \u010D\u00EDpku d\u011Blo\u017En\u00EDho. Vy\u0161et\u0159en\u00ED bude prov\u00E1d\u011Bno na lymfocytech z perifern\u00ED krve metodou PCR. V\u00FDsledky maj\u00ED umo\u017Enit c\u00EDlenou individualizaci d\u00E1vek a techniky radioterapie s p\u0159edpokl\u00E1danou redukc\u00ED jejich komplikac\u00ED." . . "10"^^ . "10"^^ . . " radiotherapy" . . " late toxicity" . "2013-12-31+01:00"^^ . . "The aim of the project is to analyse a predictive influence of ATM gene mutation and TGF\u00DF protein polymorphism upon the risk of late treatment complications in patients with locally advanced cervical carcinoma treated with radical chemoradiation. ATM mutation and TGF\u00DF polymorphism will be examined from peripheral blood lymphocytes by PCR. The results should contribute to better capability of targeted radiotherapy dose and technique individualization with the objective of treatment morbidity reduction."@en . . "2013-03-26+01:00"^^ . . . . . . . "2010-09-01+02:00"^^ . "Genetick\u00E1 predikce pozdn\u00ED toxicity radioterapie cervik\u00E1ln\u00EDho karcinomu" . . . "NT11334" . "Treatment of cervical cancer is accompanied by the risk of late effects of radiotherapy. The work addresses the possible predicting late effects of testing gene ATM and IGF\u00DF1. There was significant relationship IGF\u00DF1, promoter XRCC2 and late effects."@en . "http://www.isvav.cz/projectDetail.do?rowId=NT11334"^^ . " ATM mutation" . "L\u00E9\u010Dba karcinomu cervixu je prov\u00E1zen rizikem pozdn\u00EDch n\u00E1sledk\u016F radioterapie. Pr\u00E1ce \u0159e\u0161\u00ED mo\u017Enou predikci pozdn\u00EDch n\u00E1sledk\u016F genetick\u00FDm testov\u00E1n\u00EDm genu ATM a genu pro TGF?1. Byl zji\u0161t\u011Bn signifikantn\u00ED vztah v genu TGF?1, promotoru XRCC2 a pozdn\u00EDmi n\u00E1sledky."@cs . " concurrent chemotherapy" . "Cervical carcinoma; radiotherapy; concurrent chemotherapy; late toxicity; ATM mutation; TGF beta"@en . "0"^^ . . "Cervical carcinoma" . "Genetic prediction of late toxicity of radiotherapy for cervical cancer"@en . . . . "1"^^ . "2014-09-02+02:00"^^ . .