. " adipokines" . . "Diet Intervention in Subjects with Type 2 Diabetes: Effect of Meal Frequency and Composition on Glucose Metabolism and Symptoms of Metabolic Syndrome"@en . . . "0"^^ . . "2014-09-02+02:00"^^ . " diabetes mellitus type 2" . "NT11238" . "The aim of the project is namely to study the effect of meal frequency and composition on glucose metabolism and other symptoms of insulin resistance in subjects with type 2 diabetes. The project has two separate parts. Effect of meal frequency on insulin resistance, insulin secretion, and hepatic fat content will be tested using a randomized crossover study, recruiting 50 patients with type 2 diabetes, who will be randomly assigned to either of two meal regimens: six meals or two meals a day with the same caloric restriction (-500 kcal/day), every regimen taking three months. At start, and after 3 and 6 months metabolism of glucose and lipids and its regulation will be thoroughly tested. Effect of different meal composition on insulin secretion and secretion of gut hormones will be tested after three different breakfasts with the same caloric content yet different composition. It will be a randomized study on 60 patients with type 2 diabetes and 60 healthy controls."@en . "2010-09-01+02:00"^^ . . " meal frequency" . "C\u00EDlem projektu je zkoumat vliv frekvence a slo\u017Een\u00ED j\u00EDdel na metabolismus gluk\u00F3zy a dal\u0161\u00ED projevy inzul\u00EDnov\u00E9 rezistence u nemocn\u00FDch s diabetem 2.typu. Projekt m\u00E1 dv\u011B samostatn\u00E9 \u010D\u00E1sti. Vliv frekvence j\u00EDdel na inzul\u00EDnovou rezistenci, sekreci inzul\u00EDnu, jatern\u00ED steatosu a vybran\u00E9 bude testov\u00E1n v randomizovan\u00E9 zk\u0159\u00ED\u017Een\u00E9 studii, do n\u00ED\u017E bude za\u0159azeno 50 nemocn\u00FDch s diabetem 2. typu, kte\u0159\u00ED budou n\u00E1hodn\u011B rozd\u011Bleni do dvou j\u00EDdeln\u00EDch re\u017Eim\u016F a konzumovat \u0161est j\u00EDdel nebo dv\u011B j\u00EDdla denn\u011B se stejnou kalorickou restrikc\u00ED (-500 kcal/den) v\u017Edy 3 m\u011Bs\u00EDce. Na za\u010D\u00E1tku studie, po 3 a po 6 m\u011Bs\u00EDc\u00EDch bude podrobn\u011B zhodnocen metabolismus gluk\u00F3zy a lipid\u016F a jeho regulace. Vliv r\u016Fzn\u00E9ho slo\u017Een\u00ED j\u00EDdla na sekreci inzul\u00EDnu a peptid\u016F ze za\u017E\u00EDvac\u00EDho traktu bude testov\u00E1n po jednor\u00E1zov\u00E9m pod\u00E1n\u00ED t\u0159\u00ED typ\u016F j\u00EDdel se stejn\u00FDm kalorick\u00FDm obsahem ale r\u016Fzn\u00FDm slo\u017Een\u00EDm. Jde o randomizovanou studii, do n\u00ED\u017E bude za\u0159azeno 60 nemocn\u00FDch s diabetem 2. typu a 60 zdrav\u00FDch kontrol." . "Dv\u011B j\u00EDdla denn\u011B vedou k v\u011Bt\u0161\u00ED redukci hmotnosti, obsahu tuku v j\u00E1trech, la\u010Dn\u00E9 glykemie, glukagonu a sn\u00ED\u017Een\u00ED inzul\u00EDnov\u00E9 rezistence ne\u017E 6 j\u00EDdel denn\u011B. V\u00FDsledky ukazuj\u00ED, \u017Ee pro diabetiky 2. typu by mohlo b\u00FDt vhodn\u011Bj\u0161\u00ED konzumovat j\u00EDdlo v ni\u017E\u0161\u00ED frekvencil"@cs . . . . "http://www.isvav.cz/projectDetail.do?rowId=NT11238"^^ . . "Insulin resistance; meal frequency; diabetes mellitus type 2; liver steatosis; adipokines; gut hormones; oxidative stress"@en . . "2013-03-26+01:00"^^ . . " gut hormones" . " liver steatosis" . . . "Dietn\u00ED intervence u nemocn\u00FDch s diabetem 2. Typu - vliv frekvence a slo\u017Een\u00ED j\u00EDdel na metabolismus gluk\u00F3zy a dal\u0161\u00ED projevy metabolick\u00E9ho syndromu" . . . "3"^^ . "0"^^ . "3"^^ . "Two meals a day reduced body weight, hepatic fat content, insulin resistance, fasting glucose insulin resistance and glucagon than six meals Our results suggest that eating meals in lower frequency could be beneficial in type 2 diabetes."@en . "Insulin resistance" . . "1"^^ . . "2013-12-31+01:00"^^ .