"chronic lymphocytic leukemia; non-canonical Wnt signaling; lymphocyte migration; prognostic and diagnostic mark"@en . "1"^^ . . " non-canonical Wnt signaling" . "P\u0159edm\u011Btem \u0159e\u0161en\u00ED p\u0159edlo\u017Een\u00E9ho projektu je objasn\u011Bn\u00ED v\u00FDznamu nekanonick\u00E9 Wnt dr\u00E1hy pro diagn\u00F3zu, ur\u010Den\u00ED progn\u00F3zy a pro molekul\u00E1rn\u00ED patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leuk\u00E9mie (CLL). C\u00EDle bude dosa\u017Eeno detailn\u00ED anal\u00FDzou exprese komponent nekanonick\u00E9 Wnt dr\u00E1hy na \u00FArovni RNA (kvantitativn\u00ED RT-PCR) a protein\u016F (Western Blotting a flowcytometrie) u klinicky dob\u0159e definov\u00FDch pacient\u016F s CLL. D\u00E1le budou analyzov\u00E1ny in vitro z\u00E1kladn\u00ED parametry (apopt\u00F3za a migrace) B-lymfocyt\u016F z pacient\u016F a to, jak jsou tyto parametry modulov\u00E1ny c\u00EDlen\u00FDmi zm\u011Bnami v expresi sou\u010D\u00E1st\u00ED nekanonick\u00E9 Wnt dr\u00E1hy." . "The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia"@en . . . . "5"^^ . . "2015-01-22+01:00"^^ . "5"^^ . "NT11217" . "chronic lymphocytic leukemia" . . . . "2014-12-31+01:00"^^ . . . . "2013-03-26+01:00"^^ . "\u00DAloha nekanonick\u00E9 Wnt signalizace v molekul\u00E1rn\u00ED patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leuk\u00E9mie" . "0"^^ . "2010-09-01+02:00"^^ . . . . " lymphocyte migration" . "http://www.isvav.cz/projectDetail.do?rowId=NT11217"^^ . "The proposed project attempts to clarify the role of non-canonical Wnt pathway in diagnosis, prognosis and in molecular pathogenesis of chronic lymphocytic leukemia (CLL). The proposed goal will be achieved by expression analysis of the components of non-canonical Wnt pathway at transcript (RT-PCR) and protein level (Western blotting and flow-cytometry) in clinically well defined CLL patients. Furthermore, we will analyze basic parameters (apoptosis, migration) of patient B-cells and how are these parameters modulated by directed modulation of non-canonical Wnt signaling."@en . . . "1"^^ . .