. . . "Plated Gene Polymorphism" . . . "Association of plated genes polymorphism connected with atherothrombosis in patients with venous thromboembolism"@en . "2014-12-31+01:00"^^ . "Plated Gene Polymorphism; Gene Mutation, Association Stu"@en . "2013-03-26+01:00"^^ . "0"^^ . " Gene Mutation" . . . "1"^^ . . "Asociace polymorfism\u016F gen\u016F krevn\u00EDch desti\u010Dek spojen\u00FDch s aterotromb\u00F3zou u pacient\u016F s \u017Eiln\u00EDm tromboembolismem" . "2015-01-22+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NT11176"^^ . "0"^^ . . . . "NT11176" . "2010-09-01+02:00"^^ . "9"^^ . . . . . "9"^^ . . "U pacient\u016F s TEN (n 1500-1700) dispenzarizovan\u00FDch v Trombotick\u00E9m centru (TC) bude sledov\u00E1na asociace TEN s polymorfismy krevn\u00EDch desti\u010Dek: GP IIIa ( rs5918), P2Y12 (rs2046934 a rs6785930), COX-1 (rs10306114), PAR-1 (rs168753), GP VI (rs1613662) a GP Ia (rs1126643). D\u00E1le bude u nemocn\u00FDch s TEN vy\u0161et\u0159en polymorfismus v oblasti 9. chromozomu 9p21 ( rs10757274), genotyp APOE a mutace Lp(a) (3798220), op\u011Bt spojovan\u00FDch s KVO a provedeno porovn\u00E1n\u00ED s ji\u017E vy\u0161et\u0159en\u00FDm kontroln\u00EDm souborem zdrav\u00FDch osob. Genetick\u00E1 studie bude u nemocn\u00FDch s TEN d\u00E1le vzta\u017Eena k parametr\u016Fm hemokoagulace, z\u00E1n\u011Btu a obecn\u00FDm rizikov\u00FDm faktor\u016Fm KVO. Ur\u010Den\u00ED v\u00FDznamn\u00FDch asociac\u00ED pak m\u016F\u017Ee b\u00FDt vyu\u017Eito k stratifikaci rizika KVO u pacient\u016F s TEN. Studie bude dopln\u011Bna o resekvenaci 9. chromozomu v oblasti 21.3 s c\u00EDlem nal\u00E9zt dal\u0161\u00ED je\u0161t\u011B nepublikovan\u00E9 mutace. P\u0159edpokl\u00E1dan\u00FD okruh z\u00E1jmu je oblast preventivn\u00ED kardiologie, angiologie, molekul\u00E1rn\u00ED biologie, hemokoagulace a patofyziologie." . . "Incidence of polymorphism of plates associated with atherosclerotic CVD: GPVI (13254T/C), P2Y12 (H1/H2 haplotype), P2Y12 (32C/T), PAR-1 (IVSn-14A/T), COX-1 (-842A/G), GPIa (807C/T), GPIIIa (PlA1/PlA2), chromosome 9p21 (rs2383206) and ApoE genotype and mutations of Lp (a) LPA rs3798220 with strong association to arterial CVD will be monitored in patients with VTE who are monitored in Thrombotic center (TC). Further more associative genetic study will be compared in patients with VTE with signs of inflammatory reaction, hemocoagulation basic signs of their risk of CVD. 6 high-risk patients (CVD/VTE) will be carried out sequencing of the suspected 9th chromosome. \u201ECase-control\u201C (associative study) will be used to express relation between genotypes, levels of metabolites and disease. Detection of statistic significant associative gene polymorphism could be in future used to individual stratification of the CVD risk in patients with VTE and their prevention."@en .