" real-time PCR" . . "0"^^ . . . . "2013-03-26+01:00"^^ . . . "Centrosome amplification and mitotic genes expression is involved in pathogenesis nad the course of multiple myeloma. The precise role as well as prognostic impact and potential role in therapeutic strategy needs to be defined by the further resarch."@en . "centrosome amplification" . "57"^^ . "2013-12-31+01:00"^^ . "57"^^ . " B-lineage cells" . . . . . " arrayCGH" . . . . " multiple myeloma" . . " mitotic disruption" . "The role of B cell lineage mitotic disruptions in multiple myeloma"@en . "Centrozom\u00E1ln\u00ED amplifikace a exprese mitotick\u00FDch gen\u016F souvis\u00ED s patogenezou a pr\u016Fb\u011Bhem mnoho\u010Detn\u00E9ho myelomu.P\u0159esnou roli, stejn\u011B jako prognostick\u00FD v\u00FDznam a \u00FAlohu v terapeutick\u00E9 strategii je nutn\u00E9 potvrdit dal\u0161\u00EDm v\u00FDzkumem i na v\u011Bt\u0161\u00EDm souboru nemocn\u00FDch."@cs . "2010-09-01+02:00"^^ . "1. Centrosome amplification presents in malignant plasma cells and probably in their precursors in multiple myeloma. 2. This project is aimed on gene analysis (Array-CGH) with detailed expression analysis of chosen structural and functional genes, involved in mitotic disruption in clonal cells in MM (RT-PCR). 3. It aims to find by RT-PCR and IF staining new prognostic markers which will be important for diagnosis, classification and prediction of MM development."@en . . "centrosome amplification; mitotic disruption; multiple myeloma; B-lineage cells; arrayCGH; real-time PCR; prognostic significance"@en . "\u00DAloha mitotick\u00E9 disrupce v B lymfocytech u mnoho\u010Detn\u00E9m myelomu" . . . "NT11154" . . "http://www.isvav.cz/projectDetail.do?rowId=NT11154"^^ . . "2014-09-02+02:00"^^ . "1"^^ . "1"^^ . "1. Centrozomov\u00E9 amplifikace se nach\u00E1z\u00ED v malign\u00EDch plazmatick\u00FDch bu\u0148k\u00E1ch a pravd\u011Bpodobn\u011B i v prekurzorech v MM. 2. Tento projekt se v\u011Bnuje genov\u00E9 anal\u00FDze (Array-CGH) s detailn\u00ED expresn\u00ED anal\u00FDzou vybran\u00FDch struktur\u00E1ln\u00EDch a funk\u010Dn\u00EDch gen\u016F, kter\u00E9 se \u00FA\u010Dastn\u00ED mitotick\u00E9 disrupce klon\u00E1ln\u00EDch bun\u011Bk v MM (RT-PCR). 3. Tento projekt pou\u017Eije RT-PCR a IF barven\u00ED pro nalezen\u00ED nov\u00FDch prognostick\u00FDch marker\u016F, kter\u00E9 budou d\u016Fle\u017Eit\u00E9 pro diagn\u00F3zu, klasifikaci a predikci MM." .