" T-lymphocytes" . "CMV infection is one of the most frequent and most serious infectious complication in patients after hematopoietic stem cell transplantation. Decrease of mortality on CMV infection after HSCT was achieved by preemptive antiviral therapy regimens guided by CMV DNAemia. Negative aspect of preemptive therapy is, that it imposes further burden of antivirotics side-effects and it increases the risk of late CMV reactivations. Evaluation of specific immunity will reveal patients that are at risk of progression to CMV disease and those that reconstituted their immunity well enough and can be spared the preemptive antiviral therapy."@en . "2013-10-31+01:00"^^ . . . " Cytomegalovirus" . "4"^^ . . . . "4"^^ . "1"^^ . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NS9996"^^ . " CD8+" . "CMV specific immune reconstitution after allogeneic hematopoietic stem cell transplantation"@en . . . . "0"^^ . . . "Infekce cytomegalovirem je jednou z nej\u010Dast\u011Bj\u0161\u00EDch a nejv\u00E1\u017En\u011Bj\u0161\u00EDch infek\u010Dn\u00EDch komplikac\u00ED u pacient\u016F po transplantaci krvetvorn\u00FDch bun\u011Bk. Sn\u00ED\u017Een\u00ED mortality CMV infekce po transplantaci bylo dosa\u017Eeno zaveden\u00EDm preemptivn\u00ED terapie antivirotiky p\u0159i n\u00E1lezu CMV DNA\u00E9mie. Negativn\u00ED str\u00E1nkou preemptivn\u00ED terapie je, \u017Ee zat\u011B\u017Euje pacienty vedlej\u0161\u00EDmi \u00FA\u010Dinky antivirotik, a zvy\u0161uje riziko pozdn\u00EDch CMV reaktivac\u00ED. Sledov\u00E1n\u00ED rekonstituce specifick\u00E9 imunity pom\u016F\u017Ee odhalit pacienty, u kter\u00FDch o\u010Dek\u00E1v\u00E1me rozvoj a komplikace CMV infekce, a naopak pacienti jejich\u017E rekonstituce specifick\u00E9 imunity je dostate\u010Dn\u00E1 a mohou b\u00FDt u\u0161et\u0159eni preeptivn\u00ED antivirotick\u00E9 l\u00E9\u010Dby." . . "2009-01-01+01:00"^^ . "New characteristics of methods for the follow-up of specific T-cell responses in patients undergoing hematopoietic stem cell transplantation. Delineation of function of T-cells realising anti-viral (anti-CMV) protective T-cell response."@en . . "Transplantation; Cytomegalovirus; CD4+; CD8+; T-lymphocytes; Reconstitution"@en . "2011-08-08+02:00"^^ . . . . . . . " CD4+" . "NS9996" . "Nov\u00E9 poznatky o metodick\u00FDch mo\u017Enostech monitorace specifick\u00E9 T-lymfocyt\u00E1rn\u00ED odpov\u011Bdi u pacient\u016F po transplantaci kmenov\u00FDch bun\u011Bk krvetvorby. Rozveden\u00ED znalost\u00ED o funkci T lymfocyt\u00E1rn\u00ED proti virov\u00E9 (anti-CMV) odpov\u011Bdi."@cs . . . "2011-12-31+01:00"^^ . "Rekonstituce specifick\u00E9 imunity proti CMV po allogenn\u00ED transplantaci kmenov\u00FDch bun\u011Bk krvetvorby" . "Transplantation" .