"2010-07-16+02:00"^^ . "NS9949" . "Stanoven\u00ED in vitro senzitivity leukemick\u00FDch bun\u011Bk u nemocn\u00FDch s chronickou myeloidn\u00ED leukemi\u00ED l\u00E9\u010Den\u00FDmi inhibitory tyrosinov\u00E9 kin\u00E1zy a jej\u00ED vyu\u017Eit\u00ED p\u0159i rozhodov\u00E1n\u00ED o l\u00E9\u010Db\u011B. Klony leukemick\u00FDch bun\u011Bk in vitro rezistentn\u00ED k imatinibu, z\u00EDskan\u00E9 od nemocn\u00FDch s Ph+ CML, jsou vy\u0161et\u0159ov\u00E1ny technologi\u00ED CGH mikroarray na skryt\u00E9 genetick\u00E9 zm\u011Bny s c\u00EDlem roz\u0161\u00ED\u0159it pozn\u00E1n\u00ED mechanism\u016F odpov\u011Bdn\u00FDch za vznik rezistence k imatinibu." . "0"^^ . "Nov\u00E1 metoda v metatologii umo\u017E\u0148uj\u00EDc\u00ED individu\u00E1ln\u00ED p\u0159\u00EDstup v l\u00E9\u010Db\u011B chronick\u00E9 myeloidn\u00ED leuk\u00E9mie."@cs . "2012-01-10+01:00"^^ . . "1"^^ . "1"^^ . " kinase" . . "The role of in vitro sensitivity to tyrosine kinase inhibitors estimation in management of patients with chronic myeloid leukemia"@en . . "Reccomendation of new haematologic method for individualization of the theray of chronic myelogenous leucemia."@en . . "2009-01-01+01:00"^^ . . . . . " inhibitor" . " sensitivity" . . " tyrosine" . . . . . "http://www.isvav.cz/projectDetail.do?rowId=NS9949"^^ . " in vitro" . . . "\u00DAloha stanoven\u00ED in vitro senzitivity k inhibitor\u016Fm tyrosinov\u00E9 kin\u00E1zy Bcr-Abl p\u0159i rozhodov\u00E1n\u00ED o l\u00E9\u010Db\u011B nemocn\u00FDch s chronickou myeloidn\u00ED leukemi\u00ED" . . "CML; tyrosine; kinase; inhibitor; in vitro; resistance; sensitivity; DNA-array"@en . " resistance" . "11"^^ . "Assessment of in vitro sensitivity of leukemic cells from patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors and its implications for the therapy management. Clones of in vitro imatinib-resistant cells, obtained from patients with Ph+ CML, are assessed for hidden genetic changes using CGH microarray with the aim to increase our knowledge of the mechanisms responsible for imatinib resistance development."@en . "11"^^ . . . "2010-12-31+01:00"^^ . . "CML" .