. " keratins" . . . . . . . "Keratinov\u00E9 fragmenty jako serologick\u00FD ukazatel u nemocn\u00FDch s alkoholickou jatern\u00ED cirh\u00F3zou" . "alcohol liver disease" . "2009-01-01+01:00"^^ . "0"^^ . . " serological markers" . "2"^^ . . "2"^^ . "S\u00E9rov\u00E9 hodnoty keratinov\u00FDch fragment\u016F M30 a TPS korelovaly v\u00FDznamn\u011B se s\u00E9rov\u00FDmi hodnotami ALT a AST. Hodnoty M30 se v\u00FDznamn\u011B li\u0161ily u pacient\u016F a zdrav\u00FDch kontrol. Vy\u0161et\u0159en\u00ED fragmentu M30 by mohlo b\u00FDt nahrazeno levn\u011Bj\u0161\u00EDm vy\u0161et\u0159en\u00EDm TPS."@cs . "1"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=NS9868"^^ . "0"^^ . . . . "NS9868" . "Serum concentration of keratin fragments M30 and TPS correlated significantly with ALT and AST. Concentration of M30 was significantly different between healthy controls and patients. Examination of M30 could be substituted by less expensive TPS."@en . "Jatern\u00ED biopsie je invazivn\u00ED vy\u0161et\u0159en\u00ED, kter\u00E9 je spojeno s \u0159adou rizik, nicm\u00E9n\u011B v nyn\u011Bj\u0161\u00ED dob\u011B je nezbytn\u00FDm vy\u0161et\u0159en\u00EDm ke stanoven\u00ED t\u00ED\u017Ee a progrese chronick\u00FDch jatern\u00EDch chorob. Keratinov\u00E9 fragmenty v sou\u010Dasn\u00E9 dob\u011B reprezentuj\u00ED velmi slibn\u00E9 serologick\u00E9 ukazatele t\u00ED\u017Ee jatern\u00EDho po\u0161ko\u017Een\u00ED v d\u016Fsledku jejich mno\u017Estv\u00ED, intracelul\u00E1rn\u00ED lokalizace a bun\u011B\u010Dn\u00E9 specificity. Do dne\u0161n\u00ED doby bylo pops\u00E1no p\u011Bt r\u016Fzn\u00FDch keratinov\u00FDch protil\u00E1tek, kter\u00E9 jsou schopny detekovat keratinov\u00E9 fragmenty p\u0159i jatern\u00EDm po\u0161kozen\u00ED. C\u00EDlem na\u0161\u00ED studie je otestovat p\u011Bt r\u016Fzn\u00FDch keratinov\u00FDch protil\u00E1tek jako prediktory stupn\u011B jatern\u00EDho po\u0161kozen\u00ED porovn\u00E1n\u00EDm s histologick\u00FDm n\u00E1lezem, s\u00E9rov\u00FDmi titry b\u011B\u017En\u011B stanovovan\u00FDch ukazatel\u016F a vy\u0161et\u0159en\u00ED FibroScanem." . "alcohol liver disease; keratins; serological markers; FibroScan"@en . . "2013-10-31+01:00"^^ . "2011-12-31+01:00"^^ . "2011-08-08+02:00"^^ . . . "Keratin fragments as serological markers in patients with alcoholic liver disease"@en . "Liver biopsy, an invasive procedure associated with various risks, is currently the only reliable method to assess the severity of chronic liver disease. Keratin fragments represent promissing serological markers of liver disease severity due to their abundance, intracellular localization and cell type specificity. Up to date, five different keratin antibodies were described, which are able to detect unique keratin fragments in serum upon liver injury. Our aim is to test five keratin antibodies as predictors of severity of cirrhosis by comparing their serum titers with the extend of histologic liver damage, serum levels of established liver injury markers and FibroScan investigation."@en . .