. . "The project provides complex view on significance of p53 mutations in CLL patients and it contributed to introduction of international suggestion of p53 mutations in CLL patients."@en . "2009-01-01+01:00"^^ . " FASAY" . . "2011-08-08+02:00"^^ . "Projekt pod\u00E1v\u00E1 komplexn\u00ED pohled na v\u00FDznam mutac\u00ED genu p53 u nemocn\u00FDch CLL a p\u0159isp\u011Bl k mezin\u00E1rodn\u00EDmu doporu\u010Den\u00ED zaveden\u00ED vy\u0161et\u0159en\u00ED muta\u010Dn\u00EDho stavu genu p53 u pacient\u016F CLL."@cs . "1. B-CLL je heterogenn\u00ED onemocn\u011Bn\u00ED, nejhor\u0161\u00ED progn\u00F3zu maj\u00ED pacienti s abnormalitami genu TP53. Dosud nen\u00ED jasn\u011B definov\u00E1n klinick\u00FD v\u00FDznam monoalelick\u00FDch a bialelick\u00FDch zm\u011Bn v genu TP53. 2. C\u00EDlem projektu je sledovat vliv jednotliv\u00FDch zm\u011Bn (mutac\u00ED a delec\u00ED) v genu TP53 na progn\u00F3zu pacient\u016F a ur\u010Dit jejich vztah k aplikaci chemoterapie. 3. Bude studov\u00E1na asociace mezi konkr\u00E9tn\u00EDmi z\u00E1m\u011Bnov\u00FDmi mutacemi v genu TP53 a klinick\u00FDm pr\u016Fb\u011Bhem onemocn\u011Bn\u00ED. 4. Pro zp\u0159esn\u011Bn\u00ED muta\u010Dn\u00EDch anal\u00FDz budou st\u00E1vaj\u00EDc\u00ED metodiky (funk\u010Dn\u00ED anal\u00FDza FASAY/sekvenov\u00E1n\u00ED) dopln\u011Bny o modern\u00ED metodick\u00E9 p\u0159\u00EDstupy: sekvenov\u00E1n\u00ED na \u010Dipu, anal\u00FDza k\u0159ivek t\u00E1n\u00ED." . " prognostic marker" . . . . "NS9858" . "Prognostick\u00E1 stratifikace CLL pacient\u016F dle genetick\u00FDch zm\u011Bn v genu TP53 - vyhled\u00E1v\u00E1n\u00ED mutac\u00ED funk\u010Dn\u00ED anal\u00FDzou a modern\u00EDmi metodami" . "2011-12-31+01:00"^^ . . . . "B-CLL" . "0"^^ . . "2013-10-31+01:00"^^ . "0"^^ . "B-CLL; prognostic marker; p53; FASAY; sequencing microarrays"@en . "1"^^ . . . "1. B-CLL is a heterogeneous malignant disease; the worst prognosis is connected with abnormalities of the TP53 gene. The clinical significance of monoallelic vs. biallelic alterations is not defined as yet. 2. Aim of the project is monitoring of the association of individual alterations (mutations and deletions) with prognosis and application of therapy. 3. The association of particular missense mutations with clinical outcome will be studied. 4. To perform more precise mutational analysis, the modern approaches (microarray resequencing, High Resolution Melting) will be introduced together with established methods (functional analysis FASAY/sequencing)."@en . "http://www.isvav.cz/projectDetail.do?rowId=NS9858"^^ . "Prognostic stratification of CLL patients according to genetic alterations of TP53 gene - detection of mutations using functional analysis in combination with modern approaches"@en . . . . . "8"^^ . "8"^^ . " p53" . . . .