. . . . "NS9835" . "\u00DAloha neuroaktivn\u00EDch steroid\u016F a dal\u0161\u00EDch hormon\u00E1ln\u00EDch ukazatel\u016F v diagnostice a l\u00E9\u010Db\u011B schizofrenie" . . " autoimmunity" . . " modulators" . . . "http://www.isvav.cz/projectDetail.do?rowId=NS9835"^^ . . "0"^^ . . "schizofrenia; neuroactive steroids; neurotransmission; modulators; autoimmunity; homocysteine; dehydroepiandrosterone"@en . . . . "2013-10-31+01:00"^^ . "1"^^ . "1"^^ . "The role of neuroactive steroids and other hormonal parameters in diagnostics and treatment of schizofrenia"@en . "The project deals with the tsudy of changes of steroid metabolites in schizophrenia. The results indikates that examination of steroid metobolites can contributes to the early diagnosis of schizophrenia."@en . " neuroactive steroids" . . "Schizofrenie p\u0159edstavuje z\u00E1va\u017En\u00E9 onemocn\u011Bn\u00ED s vysok\u00FDm rizikem suicidia. Mezi biochemick\u00E9 faktory je\u017E ovliv\u0148uj\u00ED vznik a rozvoj choroby pat\u0159\u00ED neuroaktivn\u00ED steroidy, p\u016Fsob\u00EDc\u00ED jako modul\u00E1tory receptor\u016F pro neurotransmitery. C\u00EDlem projektu je p\u0159isp\u011Bt k objasn\u011Bn\u00ED vzniku choroby, naj\u00EDt nov\u00E9 laboratorn\u00ED ukazatele pro odhalen\u00ED jej\u00ED p\u0159\u00ED\u010Diny, zd\u016Fvodnit terapeutick\u00E9 pod\u00E1v\u00E1n\u00ED neuroaktivn\u00EDch steroid\u016F a ov\u011B\u0159it hypot\u00E9zu o \u00FAloze (auto)imunitn\u00EDch pochod\u016F p\u0159i vzniku schizofrenie. Budou vy\u0161et\u0159eny hladiny neuroaktivn\u00EDch steroid\u016F spolu s laboratorn\u00EDmi ukazateli endokrinn\u00EDch autoimunitn\u00EDch pochod\u016F a s dal\u0161\u00EDmi l\u00E1tkami zn\u00E1m\u00FDmi jako rizikov\u00E9 faktory onemocn\u011Bn\u00ED u pacient\u016F p\u0159ed a v pr\u016Fb\u011Bhu l\u00E9\u010Dby antipsychotiky a u kontroln\u00ED skupiny. O\u010Dek\u00E1v\u00E1me, \u017Ee zjist\u00EDme rozd\u00EDly v hladin\u00E1ch sledovan\u00FDch l\u00E1tek mezi zdrav\u00FDmi a nemocn\u00FDmi, zji\u0161t\u011Bn\u00ED nakolik sledovan\u00E9 ukazatele koreluj\u00ED a jak jsou ovlivn\u011Bny l\u00E9\u010Dbou. P\u0159isp\u011Bjeme k ov\u011B\u0159en\u00ED hypot\u00E9zy o \u00FAloze autoimunitn\u00EDch pochod\u016F v etiopatogenezi choroby." . . "Schizofrenia represents a serious disease, with a high risk of suicide. To biochemical factors affecting its origination and development belong neuroactive steroids, acting as modulators of certain receptors for neurotransmitters. The aim is to contribute to elucidation of its etiopathogenesis, to find out new laboratory diagnostic parameters, to give reasons for neuroactive steroid therapy and to verify the hypothesis on involvement of (auto)immunity in schizofrenia. The levels of neuroactive steroids will be investigated along with other laboratory parameters of endocrine autoimmune processes and selected risk factors in patients before and during treatment with antipsychotics and in controls. We expect to find out changes in the above parameters among the groups, whether they mutually correlate and are affected by the treatment. We contribute to verification of hypothesis on the role of autoimmunity in the pathogenesis of the disease."@en . "5"^^ . "5"^^ . . . "Projekt se t\u00FDk\u00E1 zejm\u00E9na zm\u011Bn spektra steroidn\u00EDch metabolit\u016F u schizofrenie. V\u00FDsledky nazna\u010Duj\u00ED, \u017Ee vy\u0161et\u0159en\u00ED spektra steroidn\u00EDch metabolit\u016F by mohlo p\u0159isp\u011Bt k \u010Dasn\u00E9 diagnostice tohoto onemocnen\u00ED. ."@cs . . "schizofrenia" . "2009-01-01+01:00"^^ . . " homocysteine" . "2011-08-08+02:00"^^ . "2011-12-31+01:00"^^ . " neurotransmission" .