. "2011-12-31+01:00"^^ . . "cancer; breast; chemotherapy; prediction; metabolism; genomics; genotype; phenotype"@en . " prediction" . . "NS9799" . "Study of relation between expression profiles in tumor tissue and result of chemotherapy of breast carcinomas"@en . "A number of candidate genetic biomarkers of bread cancer prognosis and chemotherapy efficacy was discovered in the frame of this project.SOD3, ABCC8 and PRC1 belong to the most interesting candidates.Validity,utility will be evalued in follow up studies."@en . "0"^^ . . . "1"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NS9799"^^ . . "cancer" . "2"^^ . "2013-10-31+01:00"^^ . "C\u00EDlem projektu je nalezen\u00ED ukazatel\u016F predikce v\u00FDsledku chemoterapie u pacientek s karcinomem prsu. V n\u00E1dorech pacientek budou hled\u00E1ny rozd\u00EDly v expresi funk\u010Dn\u011B d\u016Fle\u017Eit\u00FDch skupin gen\u016F a sou\u010Dasn\u011B bude hodnocena l\u00E9\u010Debn\u00E1 odpov\u011B\u010F na standartn\u00ED chemoterapii. Nalezen\u00E9 ukazaltele budou validov\u00E1ny pomoc\u00ED studia mechanismu jejich p\u016Fsoben\u00ED anal\u00FDzou genetick\u00E9ho polymorfismu a fenotypu odpov\u00EDdaj\u00EDc\u00EDch protein\u016F. Projekt nav\u00E1\u017Ee na \u0159adu studi\u00ED ji\u017E rozpracovan\u00FDch \u0159e\u0161itelsk\u00FDm pracovi\u0161t\u011Bm." . . " chemotherapy" . . " genomics" . "Sledov\u00E1n\u00ED \u00FA\u010Dinnosti l\u00E9\u010Dby karcinomu prsu v z\u00E1vislosti na expresn\u00EDch profilech v n\u00E1dorov\u00E9 tk\u00E1ni" . . . "Major aim of this project is search for markers of prediction of breast cancer chemotherapy result. Differences in expression of groups of functionally relevant genes will be followed in tumors of patients and compared to chemotherapy outcomes. Revealed predictive markers will be validated by confirmation of mechanism of action using analysis of genetic polymorphism and phenotype of corresponding proteins. The project will continue in previous studies of principal investigator in the same area."@en . " breast" . . " genotype" . . . . . . "2011-08-08+02:00"^^ . " metabolism" . "B\u011Bhem \u0159e\u0161en\u00ED projektu byla nalezena \u0159ada gen\u016F, kter\u00E9 p\u0159edstavuj\u00ED kandid\u00E1tn\u00ED biomarkery progn\u00F3zy a \u00FA\u010Dinnosti chemoterapie karcinomu prsu. Mezi nejzaj\u00EDmav\u011Bj\u0161\u00ED kandid\u00E1ty pat\u0159\u00ED SOD3, ABCC8 a PRC1. Validita a utilita biomarker\u016F se ov\u011B\u0159\u00ED v dal\u0161\u00EDch studi\u00EDch."@cs . "5"^^ . . "5"^^ . . . "2009-01-01+01:00"^^ .