" placenta" . . " sex hormones" . " puerperium" . "Neuroaktivn\u00ED steroidy v diagnostice poporodn\u00EDch du\u0161evn\u00EDch poruch" . " fetal adrenal" . . "http://www.isvav.cz/projectDetail.do?rowId=NS9790"^^ . . "Neuroactive steroids in diagnostics of postpartum mental disorders"@en . . "Jako nejlep\u0161\u00ED prediktory poporodn\u00ED deprese byly zji\u0161t\u011Bny testosteron a estrogeny."@cs . "2013-10-31+01:00"^^ . "Poporodn\u00ED du\u0161evn\u00ED poruchy (PPMD) postihuj\u00ED v\u00EDce ne\u017E polovinu \u017Een, p\u0159edstavuj\u00ED riziko ohro\u017Euj\u00EDc\u00ED zdravotn\u00ED stav matky i d\u00EDt\u011Bte a jejich d\u016Fsledky zat\u011B\u017Euj\u00ED zdravotn\u00ED syst\u00E9m. Zat\u00EDm neexistuje v\u0161eobecn\u011B p\u0159ij\u00EDman\u00E1 teorie o p\u0159\u00ED\u010Din\u00E1ch a mechanismech PPMD. PPMD patrn\u011B souvisej\u00ED s odstran\u011Bn\u00EDm placenty a fet\u00E1ln\u00ED nadledviny jako hlavn\u00EDch zdroj\u016F kortikoliberinu (CRH) a sexu\u00E1ln\u00EDch i neuroaktivn\u00EDch steroid\u016F (NS) v t\u011Bhotenstv\u00ED a se schopnost\u00ED receptorov\u00FDch syst\u00E9m\u016F se na tyto zm\u011Bny adaptovat. Na\u0161\u00EDm c\u00EDlem je zhodnotit zm\u011Bny ve hladin\u00E1ch CRH, ACTH, gonadotropin\u016F, vazebn\u00FDch protein\u016F, thyroidn\u00EDch hormon\u016F, stresov\u00FDch hormon\u016F, kortikoid\u016F, pohlavn\u00EDch a neuroaktivn\u00EDch steroid\u016F ve vztahu k PPMD. Bude sestaven model pro odhad rizika poporodn\u00ED deprese. Budeme zji\u0161\u0165ovat mo\u017En\u00E9 mechanismy PPMD. P\u0159edpokl\u00E1d\u00E1me vy\u0161\u0161\u00ED hladiny neuroinhibi\u010Dn\u00EDch substanc\u00ED p\u0159ed n\u00E1stupem porodu jejich rychlej\u0161\u00ED pokles postpartum a ni\u017E\u0161\u00ED hladiny u PPMD pozitivn\u00EDch \u017Een." . "About 50% of women suffer from puerperal mental diseases (PPMD) jeopardizing mother's and newborn's health. The consequences of PPMD burden the health system. There is no generally accepted theory explaining the causes and mechanisms of PPMD. It is likely, that PPMD is linked to the elimination of placenta and fetal adrenal being the main sources of CRH and sex and neuroactive steroids (NS) in pregnancy as well as to the ability of receptors systems to cope with the changes. We intend to evaluate changes in the levels of CRH, ACTH, gonadotropins, binding proteins, thyroid hormones, stress hormones, sex and neuroactive steroids in relation to the occurrence and intensity of PPMD. We will estimate the risk of postpartum depression and the mechanisms of PPMD will be investigated. We expect higher levels of neuroinhibiting substances before the parturition but their faster drop and lower levels in PPMD positive women postpartum."@en . . . "2011-08-08+02:00"^^ . " depression" . . . "We found cahnges in steroidogenesis that predicted the development of postpartum depression already four weeks before birth. The best predictors were steroids after the third trimester in maternal blood and steroids in mixed umbilical cord blood."@en . . "4"^^ . . "4"^^ . "1"^^ . . "1"^^ . "neuroactive steroids; CRH; puerperium; depression; placenta; fetal adrenal; sex hormones; prediction models"@en . "NS9790" . . " CRH" . "neuroactive steroids" . . "0"^^ . "2011-12-31+01:00"^^ . "2009-01-01+01:00"^^ . . . . . .