"2010-07-16+02:00"^^ . "NS9739" . . . . "Na modelu extrabili\u00E1rn\u00ED cholest\u00E1zy navozen\u00E9 podvazem choledochu bude sledov\u00E1n \u00FA\u010Dinek pod\u00E1v\u00E1n\u00ED fluvastatinu na rozvoj jatern\u00EDho po\u0161kozen\u00ED. K hodnocen\u00ED budou pou\u017Eity markery jatern\u00EDho po\u0161kozen\u00ED (ALT, AST) a cholest\u00E1zy, produkce z\u00E1n\u011Btliv\u00FDch cytokin\u016F, m\u00EDra oxida\u010Dn\u00EDho stresu a funkce mitochondri\u00ED. Projekt m\u00E1 za c\u00EDl odhalit mechanizmus p\u0159\u00EDpadn\u00E9ho terapeutick\u00E9ho \u00FA\u010Dinku statin\u016F v\u010Detn\u011B vlivu na funkci mitochondri\u00ED, z\u00E1vislost na pou\u017Eit\u00E9 d\u00E1vce l\u00E1tky a dob\u011B zah\u00E1jen\u00ED jej\u00EDho pod\u00E1v\u00E1n\u00ED (po\u010Det dn\u00ED od proveden\u00E9ho podvazu)." . "0"^^ . " lipoperoxidation" . . " glutathione" . . " fluvastatin" . "cholestasis; liver; fluvastatin; glutathione; lipoperoxidation; cytokines"@en . "Extrahepatic cholestasis will be induced by the method of common bile duct ligation. The potential effect of fluvastatin attenuating the development of cholestatic liver injury will be evaluated by the mesurements of the markers of liver injury - ALT, AST, determination of cholestasis, inflammation, oxidative stress and mitochondrial function. The project should disclose the mechanisms of potential curative effect of statins including the effect on mitochondria function and the dose- and time-dependance."@en . "1"^^ . "Pod\u00E1v\u00E1n\u00ED fluvastatinu potkan\u016Fm s cholest\u00E1zou nevedlo ke zm\u00EDrn\u011Bn\u00ED rozvoje cholestatick\u00E9ho po\u0161kozen\u00ED jater, ale naopak k jeho progresi. V\u00FDsledek projektu ukazuje na pravd\u011Bpodobn\u00E9 vysok\u00E9 riziko l\u00E9\u010Dby statiny u pacient\u016F s cholestatick\u00FDm jatern\u00EDm po\u0161kozen\u00EDm."@cs . . "cholestasis" . "3"^^ . "0"^^ . "3"^^ . . " liver" . "The use of fluvastatine in white rat with cholestasis did not led to reduction of liver tissue damage but contrariwise to the progression. This results show that there is probably high risk of statin therapy in patient with cholestatic liver disease."@en . . . "Can Statins Attenuate a development of cholestatic liver disease?"@en . . . . . "2009-01-01+01:00"^^ . . "Mohou statiny zm\u00EDrnit rozvoj cholestatick\u00E9ho jatern\u00EDho po\u0161kozen\u00ED ?" . "http://www.isvav.cz/projectDetail.do?rowId=NS9739"^^ . "2010-12-31+01:00"^^ . . . . . . "2012-01-10+01:00"^^ .