. . . "http://www.isvav.cz/projectDetail.do?rowId=NS9707"^^ . . . "Liver transplantation" . "2011-06-30+02:00"^^ . . . " Apoptosis" . . . . . "Prevalence, causes, progress, and significance of liver allograf steatosis"@en . " Survival" . . "Liver transplantation; Steatosis; Oxidative stress; Apoptosis; Survival; Insulin resistance; TNF-alpha"@en . " Oxidative stress" . . . "Determination of the prevalence, development and importance of liver transplant steatosis based on retrospective/prospective follow-up of liver transplant recipients. A histologically-based study. The involvement and importance of factors implicated in theory of two hits of the onset of steatosis: polymorphisms of genes crucial for oxidative stress, hepatocyte apoptosis, and onset of fibrosis (IL-1, IL-6, IL-10, TNF-alpha, activated caspase 3 and 7) and the effect of immunosuppression. Evaluation will be made by comparing values obtained from subjects and paired controls including standard protocol-based biopsy specimens from both study arms."@en . "Hodnocen\u00ED prevalence, v\u00FDvoje a v\u00FDznamu steat\u00F3zy jatern\u00EDho \u0161t\u011Bpu na z\u00E1klad\u011B retrospektivn\u011B-prospektivn\u00EDho sledov\u00E1n\u00ED pacient\u016F po transplantaci jater. Histologicky dolo\u017Een\u00E1 studie. Budeme zkoumat uplatn\u011Bn\u00ED a v\u00FDznam faktor\u016F v\u00FDznamn\u00FDch v teorii dvoj\u00EDho z\u00E1sahu vzniku steat\u00F3zy: polymorfizmy gen\u016F se z\u00E1sadn\u00EDm v\u00FDznamem pro oxida\u010Dn\u00ED stress, apopt\u00F3zu jatern\u00EDch bun\u011Bk a vznik fibr\u00F3zy (IL-1 IL-6, IL-10, TNF-alfa, aktivovan\u00E1 caspasa 3 a 7) a vlivu pod\u00E1van\u00E9 imunosuprese. Hodnocen\u00ED provedeme porovn\u00E1n\u00EDm zji\u0161t\u011Bn\u00FDch hodnot proband\u016F a p\u00E1rov\u00FDch kontrol v\u010Detn\u011B standardn\u011B prov\u00E1d\u011Bn\u00FDch protokol\u00E1rn\u00EDch biopsii v obou v\u011Btv\u00EDch." . "0"^^ . "2013-10-31+01:00"^^ . "V\u00FDskyt jatern\u00ED statozy u 752 transplantovan\u00FDch jater byl v 55%, v\u00FDskyt NASH v 6,2%.Rizikov\u00FDmi faktory steat\u00F3zy \u0161t\u011Bpu byla mimo jin\u00E9 vy\u0161\u0161\u00ED hodnota BMI a triglycerid\u016F. Ke kvantifikaci tuku v jatern\u00ED tk\u00E1ni je vhodnou metodou MR spektroskopie."@cs . "1"^^ . "NS9707" . "3"^^ . " Steatosis" . "0"^^ . "3"^^ . "V\u00FDskyt, p\u0159\u00ED\u010Diny, v\u00FDvoj a v\u00FDznam steat\u00F3zy \u0161t\u011Bpu u pacient\u016F po transplantaci jater" . . " Insulin resistance" . . "2009-01-01+01:00"^^ . . "Steatosis was found in 55% of 752 transplanted livers, NASH in 6,2 % . Risk faktors for steatosis were higher value of BMI and triglycerides. MR spectroscopy is an appropriate method for steatosis quantification."@en . . . .