"The aim of the study is to investigate serum tissue transglutaminase antibodies (tTG) IgG and IgA in patient with liver injury of various reasons including hepatocelullar carcinoma. Approximately five hundred patients will be included into the study. Statistical analysis will be performed using non-parametric Mann-Whitney test. Analysis of endomysial antibodies will be performed in patients with positive results to tTG. Analysis of antibodies specificity against tTG could an important marker in auto reactivity of patients with liver injury and celiac disease. The other aim of our study is characterization of antigen epitopes of tTG recognized by antibodies of IgA isotype in patients with liver disease using a PEPSCAN method. Our study will include the patients after liver transplantation as well. In patients with confirmed celiac disease a liver biopsy and duodenal mucosal biopsy with imunohistochemical evaluation will be performed."@en . "liver disease; celiac disease; liver transplantation; gluten-free diet; tissue transglutaminase; autoimmune hepatitis"@en . . . . . . . "It was found: Higher incidence of celiac disease in patients with liver diseases (incl. Wilson disease), pronounced expression of tissue transglutaminase in liver of these patients, high level of anticalreticulin antibodies in hepatocellular cancer pts."@en . . "liver disease" . "The association of chronic liver disease with coeliac disease"@en . " gluten-free diet" . "Byl prok\u00E1z\u00E1n vy\u0161\u0161\u00ED v\u00FDskyt cekiakie u pac. s jatern\u00EDmi chorobami (nov\u011B i. Wilsoniovy choroby), d\u00E1le zv\u00FD\u0161en\u00E1 exprese tk\u00E1\u0148ov\u00E9 transglutamin\u00E1zy v j\u00E1trech t\u011Bchto pacient\u016F, vysok\u00FD v\u00FDskyt antkalretikulinov\u00FDch protil\u00E1tek u pacient\u016F s hepatocelul\u00E1rn\u00EDm karcinomem"@cs . "2011-12-31+01:00"^^ . "2009-01-01+01:00"^^ . "2011-08-08+02:00"^^ . "3"^^ . . "0"^^ . "2013-10-31+01:00"^^ . "3"^^ . "1"^^ . " liver transplantation" . "C\u00EDlem projektu je stanovit souvislost mezi jatern\u00EDmi onemocn\u011Bn\u00ED a celiaki\u00ED u jinak asymptomatick\u00FDch jedinc\u016F jako projev extraintestin\u00E1ln\u00ED manifestace celiakie v souboru pacient\u016F IKEM jak p\u0159ed tak i po transplantaci jater v\u010Detn\u011B sledov\u00E1n\u00ED efektu bezlepkov\u00E9 diety. Zam\u011B\u0159\u00EDme se na anal\u00FDzu detailn\u00ED specificity autoprotil\u00E1tek proti tk\u00E1\u0148ov\u00E9 transglutamin\u00E1ze k odhalen\u00ED mo\u017En\u00FDch p\u0159\u00ED\u010Din autoreaktivity pacient\u016F s jatern\u00EDmi onemocn\u011Bn\u00EDm a floridn\u00ED celiaki\u00ED. Sou\u010D\u00E1st\u00ED bude i imunohistochemick\u00E9 vy\u0161et\u0159en\u00ED bioptick\u00FDch vzork\u016F duodena a jater u indikovan\u00FDch jedinc\u016F. Dal\u0161\u00EDm c\u00EDlem je charakterizace antigenn\u00EDch epitop\u016F tk\u00E1\u0148ov\u00E9 transglutamin\u00E1zy rozpozn\u00E1van\u00FDch s\u00E9rov\u00FDmi IgA protil\u00E1tkami pacient\u016F s aktivn\u00ED celiaki\u00ED a s\u00E9ropozitivn\u00EDch pacient\u016F s hepatopatiemi." . "http://www.isvav.cz/projectDetail.do?rowId=NS9705"^^ . . " celiac disease" . . . "0"^^ . . " tissue transglutaminase" . . . "VZTAH JATERN\u00CDCH ONEMOCN\u011AN\u00CD A CELIAKIE" . . "NS9705" . . . .