"10"^^ . "10"^^ . "P\u0159edm\u011Btem t\u00E9to grantov\u00E9 aplikace je ov\u011B\u0159en\u00ED zda inhibitory solubiln\u00ED epoxide hydrol\u00E1zy (sEH), zvy\u0161uj\u00EDc\u00ED koncentraci epoxyeikosatrienov\u00FDch kyselin (EETs) ve tk\u00E1n\u00EDch, mohou p\u0159edstavovat potenci\u00E1ln\u011B nov\u00FD p\u0159\u00EDstup v antihypertenzn\u00ED terapii. Bude proto testov\u00E1n \u00FA\u010Dinek inhibitoru sEH, cis-4-[4-(3-Adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoov\u00E9 kyseliny (c-AUCB) na krevn\u00ED tlak ren\u00E1ln\u00ED funkce a tk\u00E1\u0148ov\u00E9 po\u0161kozen\u00ED ledvin u modelu renovaskul\u00E1rn\u00ED hypertenze." . "NS9699" . . "We found that the reduced intrarenal bioavailability natriuretic EETs contributes to the pathophysiology of renovascular hypertension and that pharmacological blockade of sEH appears to be a new approach for the treatment of this form of hypertension."@en . . . . "Sn\u00ED\u017Een\u00E1 intraren\u00E1ln\u00ED dostupnost natriuretick\u00FDch EETs v\u00FDznamn\u00FDm zp\u016Fsobem p\u0159isp\u00EDv\u00E1 k patofyziologii renovaskul\u00E1rn\u00ED hypertense a chronick\u00E1 blok\u00E1da solubiln\u00ED epoxid hydrol\u00E1zy se jev\u00ED jako nov\u00FD terapeutick\u00FD ter\u010D pro l\u00E9\u010Dbu t\u00E9to formy hypertense."@cs . "2009-01-01+01:00"^^ . . " renal injury" . "This proposal is designed to determine whether inhibitors of soluble epoxide hydrolase (sEH), increasing endogenous level of epoxyeicosatrienoic acids (EETs), could be a potential new approach in antihypertensive drug therapy. An effects of novel sEH inhibitor, cis-4-[4-(3-Adamantan-1-yl-ureido)-cyclohexyl-oxy]-benzoic acid (c-AUCB) on blood pressure, renal function and renal injury will be tested in Goldblatt two kidney one clip (2K1C) rat model of renovascular hypertension."@en . . . . . . " renovascular hypertension" . . . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NS9699"^^ . "\u00DAloha zv\u00FD\u0161en\u00FDch koncentrac\u00ED epoxyeikosatrienov\u00FDch kyselin v regulaci ren\u00E1ln\u00EDch funkc\u00ED a patofyziologii renovaskul\u00E1rn\u00ED hypertenze" . "0"^^ . "epoxyeicosatrienoic acids; epoxide hydrolase; renovascular hypertension; renal injury; renal function; antihypertensive therapy"@en . . . "0"^^ . . " epoxide hydrolase" . "2011-12-31+01:00"^^ . "2013-10-31+01:00"^^ . . . "2011-08-08+02:00"^^ . "epoxyeicosatrienoic acids" . " renal function" . . "The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension"@en .