. "Mechanismy a d\u016Fsledky akumulace lipid\u016F v j\u00E1trech p\u0159i metabolick\u00E9m syndromu - mo\u017Enosti nutri\u010Dn\u00ED a farmakologick\u00E9 intervence" . " liver lipases" . . . . " Kupffer cells" . "The targets of project were fulfilled in time with excelent results - 5 articles published in journals with IF, 14 abstracts from conferences. Suggested evaluation A."@en . . . . "1"^^ . "C\u00EDle projektu byly spln\u011Bny v term\u00EDnu s v\u00FDborn\u00FDmi v\u00FDsledky - 5 prac\u00ED publikovan\u00FDch v \u010Dasopisech s IF a dal\u0161\u00EDch 14 abstrakt ze sjezd\u016F. Navrhuji hodnocen\u00ED v kategorii A."@cs . . "1"^^ . . . "2011-08-08+02:00"^^ . . . " insulin resistance" . "2011-12-31+01:00"^^ . "0"^^ . "2009-01-01+01:00"^^ . "NS9696" . . "http://www.isvav.cz/projectDetail.do?rowId=NS9696"^^ . . "NAFLD; insulin resistance; cytokines; Kupffer cells; liver lipases; metabolic syndrome; adipose tissue; oxidative stress"@en . . "1. The IR associated mechanisms determining the impaired ability of adipose tissue to regulate the release and uptake of FFA with respect to the NAFLD development. 2. The role of intensified intracellular Tg turnover due to stimulated activity of lysosomal lipase in NAFLD with respect to the activation of systems inducing hepatic IR via increased production of lipid metabolism intermediates and possible destabilisation of lysosomes. 3. The role of resident macrophages in the development of dietary induced IR, ROS production and endotoxin sensitivity. 4. The effect of the increased reactive oxygen species load provoked by the depletion of antioxidant systems on the severity of hepatic IR and liver injury in NAFLD."@en . "NAFLD" . " adipose tissue" . "1. Ve vztahu ke vzniku jatern\u00ED steat\u00F3zy budou sledov\u00E1ny mechanismy podmi\u0148uj\u00EDc\u00ED poruchy schopnosti tukov\u00E9 tk\u00E1n\u011B regulovat p\u0159i inzul\u00EDnov\u00E9 rezistenci uvol\u0148ov\u00E1n\u00ED a vychyt\u00E1v\u00E1n\u00ED mastn\u00FDch kyselin. 2. Bude testov\u00E1n p\u0159edpoklad, \u017Ee zv\u00FD\u0161en\u00FD intracelul\u00E1rn\u00ED obrat Tg v d\u016Fsledku akcentovan\u00E9 \u010Dinnosti jatern\u00ED lysozom\u00E1ln\u00ED lip\u00E1zy p\u0159i jatern\u00ED steat\u00F3ze vede k destabilizaci lysozom\u016F a k aktivaci syst\u00E9m\u016F navozuj\u00EDc\u00EDch jatern\u00ED inzul\u00EDnovou rezistenci. 3. Budou sledov\u00E1ny mechanismy podmi\u0148uj\u00EDc\u00ED produkci reaktivn\u00EDch slou\u010Denin kysl\u00EDku a jatern\u00EDch cytokin\u016F p\u0159i jatern\u00ED steat\u00F3ze se zvl\u00E1\u0161tn\u00EDm z\u0159etelem k \u00FAloze rezidentn\u00EDch makrof\u00E1g\u016F. 4. Po indukci oxida\u010Dn\u00EDho stresu v d\u016Fsledku deplece antioxida\u010Dn\u00EDch syst\u00E9m\u016F bude sledov\u00E1n vliv zv\u00FD\u0161en\u00E9 z\u00E1t\u011B\u017Ee reaktivn\u00EDmi slou\u010Deninami kysl\u00EDku p\u0159i jatern\u00ED steat\u00F3ze na rozvoj inzul\u00EDnov\u00E9 rezistence a po\u0161kozen\u00ED jater." . " cytokines" . "8"^^ . "2013-10-31+01:00"^^ . "8"^^ . . . . "Mechanisms and consequences of the accumulation of lipids in liver associated with metabolic syndrome - the possibilities of nutritional and pharmacological intervention"@en . " metabolic syndrome" .