"2012-01-10+01:00"^^ . "Measurement of the alveolar concentration and bronchial output of nitric oxide requires further standartization and it has no added value for the treatment of children with asthma over the standard measurement at the expiratory flow of 50 ml/s."@en . . . " allergy" . "Noninvasive methods for evaluation of exhaled nitric oxide as a biomarker of airway inflammation in children with seasonal allergic rhinitis and bronchial asthma"@en . "Alergick\u00E1 onemocn\u011Bn\u00ED d\u00FDchac\u00EDch cest jsou nej\u010Dast\u011Bj\u0161\u00EDmi chronick\u00FDmi onemocn\u011Bn\u00EDmi d\u011Bt\u00ED a dosp\u00EDvaj\u00EDc\u00EDch (prevalence alergie 15-25%, prevalence pr\u016Fdu\u0161kov\u00E9ho astmatu 8-15%). P\u0159i diagn\u00F3ze a sledov\u00E1n\u00ED pr\u016Fb\u011Bhu terapie t\u011Bchto onemocn\u011Bn\u00ED se v sou\u010Dasnosti st\u00E1le v\u00EDce uplat\u0148uje neinvazivn\u00ED vy\u0161et\u0159en\u00ED oxidu dusnat\u00E9ho ve vydechovan\u00E9m vzduchu (FENO), kter\u00E9 odr\u00E1\u017E\u00ED p\u0159\u00EDtomnost eozinofiln\u00EDho z\u00E1n\u011Btu v d\u00FDchac\u00EDch cest\u00E1ch. V popula\u010Dn\u00ED studii bude vy\u0161et\u0159en naz\u00E1ln\u00ED oxid dusnat\u00FD a FENO chemiluminiscen\u010Dn\u00EDm analyz\u00E1torem p\u0159i 5 v\u00FDdechov\u00FDch rychlostech a p\u0159i klidov\u00E9m d\u00FDch\u00E1n\u00ED, alveol\u00E1rn\u00ED oxid dusnat\u00FD a bronchi\u00E1ln\u00ED tok oxidu dusnat\u00E9ho. Budou zji\u0161t\u011Bny \u00FAsp\u011B\u0161nost proveden\u00ED vy\u0161et\u0159en\u00ED, referen\u010Dn\u00ED hodnoty ve zdrav\u00E9 populaci, vliv r\u016Fzn\u00FDch faktor\u016F (v\u011Bk, pohlav\u00ED, aj.), opakovatelnost v\u00FDsledku a zm\u011Bny hodnot u d\u011Bt\u00ED s refluxn\u00ED chorobou j\u00EDcnu, alergickou r\u00FDmou a astmatem." . . . "http://www.isvav.cz/projectDetail.do?rowId=NS9692"^^ . . . "2010-12-31+01:00"^^ . "2010-07-16+02:00"^^ . . "0"^^ . "Allergic rhinitis and bronchial asthma belong to most frequent chronic diseases in childhooh. In the last years, exhaled nitric oxide has been recognized as a suitable method for monitoring the level of eosinophilic airway inflammation. In a cross-sectional study, exhaled nitric oxide will be evaluated using the multiple-flow technique and nasal nitric oxide will be assessed in healthy children as well as children with allergic rhinitis and bronchial asthma. The success rate, the repeatability of the test, the reference ranges for flow-independent parameters will be evaluated. The influence of demographic as wel as desease-related factors on the result of the test will be examined."@en . "asthma" . "1"^^ . . "1"^^ . . . . . "Vy\u0161et\u0159en\u00ED parametr\u016F charakterizuj\u00EDc\u00EDch alveol\u00E1rn\u00ED a bronchi\u00E1ln\u00ED zdroje oxidu dusnat\u00E9ho je nedostate\u010Dn\u011B standartizovan\u00E9 a nep\u0159in\u00E1\u0161\u00ED p\u0159i l\u00E9\u010Db\u011B d\u011Bt\u00ED s pr\u016Fdu\u0161kov\u00FDm astmatem p\u0159\u00EDdatnou informaci oproti vy\u0161et\u0159en\u00ED p\u0159i v\u00FDdechov\u00E9 rychlosti 50 ml/s."@cs . "7"^^ . "7"^^ . "Vyu\u017Eit\u00ED vydechovan\u00E9ho oxidu dusnat\u00E9ho jako biochemick\u00E9ho markeru z\u00E1n\u011Btu v d\u00FDchac\u00EDch cest\u00E1ch nemocn\u00FDch se sez\u00F3nn\u00ED alergickou r\u00FDmou a pr\u016Fdu\u0161kov\u00FDm astmatem." . . "asthma; allergy; nitric oxide; inflammation"@en . . "2009-01-01+01:00"^^ . . . . " nitric oxide" . . "NS9692" .