. "0"^^ . "NS9690" . "1"^^ . "2013-10-31+01:00"^^ . "The project goals are met in time, the hypothesis was (on a set of 10/78 patients) confirmed. The work is perfectly factually and formally processed, the results were published in refereed journals (at the time of submission 2 of 7)."@en . "2"^^ . . . "P\u0159edopera\u010Dn\u00ED region\u00E1ln\u00ED chemoterapie v l\u00E9\u010Db\u011B karcinomu tlust\u00E9ho st\u0159eva" . "6"^^ . "6"^^ . . "C\u00EDle projektu byly spln\u011Bny v \u0159\u00E1dn\u00E9m term\u00EDnu, hypot\u00E9za byla (na mal\u00E9m souboru 10/78 nemocn\u00FDch) potvrzena. Pr\u00E1ce je dokonale v\u011Bcn\u011B i form\u00E1ln\u011B zpracov\u00E1na, v\u00FDsledky byly publikov\u00E1ny v oponovan\u00FDch \u010Dasopisech (v dob\u011B odevzd\u00E1n\u00ED 2 ze 7)."@cs . "large bowel carcinoma" . . "large bowel carcinoma; liver metastasis; regional chemotherapy; overall survival; disease free survival"@en . " liver metastasis" . " overall survival" . . . . . "P\u0159edm\u011Btem projektu je p\u0159edopera\u010Dn\u00ED jatern\u00ED a region\u00E1ln\u00ED arteri\u00E1ln\u00ED chemoterapie u pacient\u016F s karcinomem tlust\u00E9ho st\u0159eva ve stadiu II nebo III. Tato terapie by m\u011Bla u zm\u00EDn\u011Bn\u00FDch pacient\u016F zlep\u0161it celkov\u00E9 p\u0159e\u017Eit\u00ED a b\u00FDt prevenc\u00ED metachronn\u00EDch jatern\u00EDch metast\u00E1z. Pacienti podstoup\u00ED p\u0159edopera\u010Dn\u00ED chemoterapii do arteria hepatica a tepny z\u00E1sobuj\u00EDc\u00ED n\u00E1dor (oxaliplatina 50 mg v 2 hodinov\u00E9 infusi, n\u00E1sledovat bude 24-hodinov\u00E1 infuse 1000 mg 5FU). Po t\u00FDdnu bude provedena pl\u00E1novan\u00E1 operace. Po operaci bude n\u00E1sledovat standardn\u00ED chemoterapie (re\u017Eim FOLFOX4, 12 cykl\u016F). Srovn\u00E1n\u00ED bude provedeno s historickou kontroln\u00ED skupinou hodnocenou retrospektivn\u011B. D\u00E9lka follow up intervalu by m\u011Bla b\u00FDt minim\u00E1ln\u011B 24 m\u011Bs\u00EDc\u016F." . . . . . "2011-08-08+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NS9690"^^ . "2011-12-31+01:00"^^ . . "This study focuses on the preoperative hepatic and regional arterial chemotherapy in patients with the large bowel carcinoma in the stages II or III. This kind of treatment should prolong the overall survival interval and prevent the uprising of the metachronous liver metastasis in these patients. Patients will undergo the preoperative chemotherapy into the hepatic artery and those arteries supplying the tumor (oxaliplatinum 50 mg in 2 hours lasting infusion, followed by the 24 hours lasting infusion of 1000 mg 5FU). A week later, the planned operation will be performed, followed by standard chemotherapy (regimen FOLFOX4, 12 cycles). The results will be compared with a historical control group assessed retrospectively. The follow-ups should last at least for 24 months."@en . . "2009-01-01+01:00"^^ . " regional chemotherapy" . . . . . "Preoperative Regional Chemotherapy in Colon Cancer Patients"@en .