. "2011-08-08+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NS9637"^^ . . . " Oncogene" . . " Nucleolus" . "Complementary methods of protein interaction analysis implementation. Comparative analysis if anticancer drugs effects on leukemic and normal cells."@en . "0"^^ . . . "0"^^ . "2"^^ . . "Leukemia; Nucleus; Nucleolus; Interaction; Oncogene; Tumorsuppressor; Apoptosis; Cytotoxic"@en . " Interaction" . "2"^^ . "1"^^ . . "2013-10-31+01:00"^^ . "Study of interactions between nuclear and nucleolar factors controlling cell proliferation and effectors of programmed cell death. Modifications and translocations during leukemogenesis and drug induced apoptosis in normal leukocytes and leukemic cells. The study of interaction complexes in normal blood cells and leukemic cell lines using: qRT-PCR, immunoblotting, yeast two-hybrid system, affinity chromatography, mass spektrometry, flow cytometry, immunofluorescence microscopy."@en . "NS9637" . . " Nucleus" . "2009-01-01+01:00"^^ . "2011-12-31+01:00"^^ . . . . . . "Interakce mezi nukle\u00E1rn\u00EDmi a nukleol\u00E1rn\u00EDmi regul\u00E1tory bun\u011B\u010Dn\u00E9 proliferace a apoptotick\u00FDmi efektory p\u0159i vzniku, rozvoji a l\u00E9\u010Db\u011B leuk\u00E9mi\u00ED" . " Apoptosis" . "Interakce mezi regul\u00E1tory bun\u011B\u010Dn\u00E9 proliferace a apoptotick\u00FDmi efektory protin\u00E1dorov\u00E9 obrany v norm\u00E1ln\u00EDch a leukemick\u00FDch bu\u0148k\u00E1ch. Zm\u011Bny tvorby a lokalizace interak\u010Dn\u00EDch komplex\u016F p\u0159i vzniku krevn\u00EDch malignit, v\u00FDznam v \u010Dasn\u00E9 diagnostice a l\u00E9\u010Db\u011B leuk\u00E9mi\u00ED. Studium interak\u010Dn\u00EDch komplex\u016F v norm\u00E1ln\u00EDch krevn\u00EDch bu\u0148k\u00E1ch a v bu\u0148k\u00E1ch leukemick\u00FDch lini\u00ED metodami: imunoblot, afinitn\u00ED chromatografie, kvasinkov\u00FD 2-hybridn\u00ED syst\u00E9m, hmotov\u00E1 spektrometrie, pr\u016Ftokov\u00E1 cytometrie, fluorescen\u010Dn\u00ED mikroskopie." . "Zaveden\u00ED komplement\u00E1rn\u00EDch metod proteinov\u00FDch interakc\u00ED. Srovn\u00E1n\u00ED mechanismu \u00FA\u010Dinsk\u016F n\u00E1dorov\u00FDch l\u00E9\u010Div na leukemick\u00E1 a zdrav\u00E9 \u02C7bu\u0148ky"@cs . . . . "Interactions between nuclear and nucleolar proteins controlling cell proliferation and apoptosis effectors during leukemogenesis and therapy of leukemias."@en . "Leukemia" . . " Tumorsuppressor" .