"2011-12-31+01:00"^^ . . . . . "0"^^ . . " LOH" . . "Molecular characteristics of borderline ovarian tumors in relation to their biological behavior"@en . "1"^^ . " BRAF" . "1"^^ . "2013-10-31+01:00"^^ . "NS10566" . . "2011-08-08+02:00"^^ . "Navrhovan\u00FD projekt se zab\u00FDv\u00E1 retrospektivn\u00EDm studiem molekul\u00E1rn\u00EDch charakteristik borderline n\u00E1dor\u016F vaje\u010Dn\u00EDk\u016F a vztahem t\u011Bchto charakteristik k biologick\u00E9mu chov\u00E1n\u00ED n\u00E1dor\u016F. V tk\u00E1n\u00EDch tumor\u016F budou zkoum\u00E1ny \u010Detnosti a zp\u016Fsoby inaktivace n\u011Bkter\u00FDch bun\u011B\u010Dn\u00FDch cest. Analyzov\u00E1ny budou jak genetick\u00E9 \u2013 mutace gen\u016F KRAS a BRAF a ztr\u00E1ta heterozygosity v chromozom\u00E1ln\u00EDch oblastech nesouc\u00EDch n\u011Bkter\u00E9 tumorsupresory -, tak epigenetick\u00E9 (metylace promotorov\u00FDch sekvenc\u00ED) zm\u011Bny. Porovn\u00E1n\u00EDm molekul\u00E1rn\u00EDch zm\u011Bn v benign\u00EDch, borderline a malign\u00EDch n\u00E1dorech vaje\u010Dn\u00EDk\u016F budou identifikov\u00E1ny zm\u011Bny d\u016Fle\u017Eit\u00E9 pro progresi n\u00E1doru v invazivn\u00ED karcinom. Z\u00EDskan\u00E1 data budou vzta\u017Eena ke klinicko-patologick\u00FDm charakteristik\u00E1m n\u00E1dor\u016F u jednotliv\u00FDch pacientek. V\u00FDsledkem pak bude model predikce biologick\u00E9ho chov\u00E1n\u00ED bordeline n\u00E1dor\u016F na z\u00E1klad\u011B jejich molekul\u00E1rn\u00EDch charakteristik. Takov\u00FDto model bude v kontextu v\u00FDzkumu borderline ovari\u00E1ln\u00EDch n\u00E1dor\u016F jedine\u010Dn\u00FD a umo\u017En\u00ED p\u0159izp\u016Fsobit terapii konkr\u00E9tn\u00EDm charakteristik\u00E1m n\u00E1doru u konkr\u00E9tn\u00ED pacientky." . . "We analyzed genetic and epigenetic changes in borderline epithelial ovarian tumors. We developed methods for molecular analysis, detected typical molecular patterns and established approaches for their use in prognosis assesment and prediction."@en . "borderline ovarian tumors" . . . "borderline ovarian tumors; prognostic factors; LOH; KRAS; BRAF; promoter methylation"@en . . . . "2009-01-01+01:00"^^ . "V r\u00E1mci projektu byly zkoum\u00E1ny genetick\u00E9 a epigenetick\u00E9 zm\u011Bny u borderline u epiteli\u00E1ln\u00EDch ovari\u00E1ln\u00EDch n\u00E1dor\u016F. Byla vyvinuta metodika molekul\u00E1rn\u00ED anal\u00FDzy,odhaleny typick\u00E9 mol. vzorce a stanoveny postupy pro jejich prognostick\u00E9 a prediktivn\u00ED vyu\u017Eit\u00ED."@cs . . . . " KRAS" . . "http://www.isvav.cz/projectDetail.do?rowId=NS10566"^^ . "This proposal is designed as a retrospective study analyzing molecular characteristics of borderline ovarian tumors and comparing these characteristics to biological behavior of tumors. We will study frequency and modalities of inactivation of certain cellular pathways in tumor tissue. Analysis will comprise wide spectrum of genomic (genetic and epigenetic) changes \u2013 mutations of oncogenes KRAS and BRAF, loss of heterozygosity in chromosomal loci harboring tumorsupressor genes and methylation of promoter sequences. Comparison of genomic changes of benign, borderline and malignant tumors will identify changes important and typical for progression to invasive disease. Collected data will be compared to clinical and pathological characteristics of concrete tumor. Model of prediction and prognosis will be reveloped as an output and is supposed to allow tailor therapy to concrete tumor characteristics in each patient."@en . " prognostic factors" . "Molekul\u00E1rn\u00ED charakteristiky borderline ovari\u00E1ln\u00EDch tumor\u016F ve vztahu k biologick\u00E9mu chov\u00E1n\u00ED n\u00E1dor\u016F" . . "7"^^ . "7"^^ . .