" gene expression" . "3"^^ . "0"^^ . "3"^^ . "2013-10-31+01:00"^^ . "1"^^ . . . . . . . "The combination of conventional histology along with intrarenal transcriptome analysis might be a useful tool to identify grafts at risk for delayed graft function and adapt the therapeutic intervention."@en . "NS10516" . "Dlouhodob\u00E9 v\u00FDsledky transplantac\u00ED ledvin jsou ovlivn\u011Bny mimo jin\u00E9 kvalitou \u0161t\u011Bpu a ischemicko-reperfuzn\u00EDm po\u0161kozen\u00EDm ledviny b\u011Bhem transplantace. V sou\u010Dasnosti nejsou k dispozici standardn\u00ED histologick\u00E9 nebo jin\u00E9 metody umo\u017E\u0148uj\u00EDc\u00ED zhodnocen\u00ED stavu ledviny p\u0159ed transplantac\u00ED a v jej\u00EDm pr\u016Fb\u011Bhu. C\u00EDlem tohoto projektu je pomoc\u00ED anal\u00FDzy genov\u00E9 exprese a biostatistiky identifikovat takov\u00E9 kandid\u00E1tn\u00ED geny, jejich\u017E zm\u011Bn\u011Bn\u00E1 m\u00EDra exprese v ren\u00E1ln\u00ED tk\u00E1ni p\u0159edpov\u00EDd\u00E1 jako biomarker z\u00E1va\u017Enost ischemicko/reperfusn\u00EDho po\u0161kozen\u00ED a tak umo\u017En\u00ED prognosticky se vyj\u00E1d\u0159it k v\u00FDsledku transplantace ledviny." . . . . . "Gene expression profiles in ischemic-reperfusion injury and its impact on renal transplantation"@en . "Profily genov\u00E9 exprese u ischemicko reperfuzn\u00EDho po\u0161kozen\u00ED a jejich v\u00FDznam pro transplantaci ledviny" . . " donor biopsy" . . . "http://www.isvav.cz/projectDetail.do?rowId=NS10516"^^ . "The long-term outcomes of renal transplantation are affected, among other things, by graft quality and ischemia-reperfusion injury to the renal graft during transplantation. No standard histological or other methods making it possible to assess the status of the kidney pre-transplant and during the procedure are currently available. The aim of the project is to determine, using mRNA profile analysis and immunohistochemical evidence of selected proteins in cadaveric donor kidney biopsies before and during reperfusion and in standard protocol biopsy at 3 months post-transplant, the predictive value of these biomarkers for assessing the quality of the donor organ and its long-term function."@en . "renal transplantation" . "2009-01-01+01:00"^^ . " TLDA" . . "2011-08-08+02:00"^^ . . "Kombinace konven\u010Dn\u00ED histologie a vy\u0161et\u0159en\u00ED specifick\u00FDch molekul\u00E1rn\u00EDch zm\u011Bn mohou b\u00FDt nov\u00FDm n\u00E1strojem pro identifikaci \u0161t\u011Bp\u016F v riziku vzniku opo\u017Ed\u011Bn\u00E9ho rozvoje funkce transplantovan\u00E9 ledviny."@cs . "renal transplantation; gene expression; TLDA; donor biopsy; ischemia/reperfusion injury"@en . "2011-12-31+01:00"^^ . . "0"^^ . . .