"0"^^ . "The interaction between renin-angiotensin and endothelin systems in the pathogenesis of renal failure and cardiac hypertrophy in hypertensive rats"@en . . "1"^^ . "Progression of chronic kidney diseases is associated with marked intrarenal activation of the RAS and ET syst\u00E9m. Treatment with RAS and ET blockers attenuated the progression of chronic kidney disease."@en . "http://www.isvav.cz/projectDetail.do?rowId=NS10500"^^ . "0"^^ . . . . "5"^^ . . "5"^^ . . " renin-angiotensin system" . "Potential additive effect of the treatment wirh endothelin receptor blocker (atrasentan) to low salt diet and renin-angiotensin system blockade in a rat model transenic for mouse renin gene and/or 5/6 nephrectomy will be studied. The aim is to further decrease the development of renal failure and cardiac hypertrophy."@en . "2013-10-31+01:00"^^ . . "2011-12-31+01:00"^^ . . " subtotal nephrectomy" . . " cardiac hypertrophy" . "2011-08-08+02:00"^^ . " endothelin" . " atrasentan" . . . "Progrese chronick\u00E9 ren\u00E1ln\u00ED insuficience je spojena s v\u00FDraznou intraren\u00E1ln\u00ED aktivac\u00ED renin-angiotenzinov\u00E9ho a endothelinov\u00E9ho syst\u00E9mu. Kombinovan\u00E1 blok\u00E1da RAS a ET vykazuje nejlep\u0161\u00ED v\u00FDsledky ve zpomalen\u00ED progrese CHRI."@cs . . . " renal failure" . "hypertension" . "2009-01-01+01:00"^^ . . " AT1 inhibitor" . "NS10500" . . . "Interakce renin-angiotenzinov\u00E9ho a endotelinov\u00E9ho syst\u00E9mu v patofyziologii progrese ren\u00E1ln\u00ED insuficience a srde\u010Dn\u00ED hypertrofie u hypertenzn\u00EDch potkan\u016F" . "Bude studov\u00E1n potenci\u00E1ln\u00ED aditivn\u00ED \u00FA\u010Dinek l\u00E9\u010Dby blok\u00E1torem endotelinov\u00FDch receptor\u016F (atrasentan) k pod\u00E1v\u00E1n\u00ED diety s n\u00EDzk\u00FDm obsahem sod\u00EDku spolu s blok\u00E1dou renin-angiotenzinov\u00E9ho syst\u00E9mu u modelu potkan\u016F transgenn\u00EDch pro my\u0161\u00ED reninov\u00FD gen a/nebo s 5/6 nefrektomi\u00ED. C\u00EDlem je dal\u0161\u00ED zpomalen\u00ED rozvoje ren\u00E1ln\u00ED insuficience a hypertrofie srde\u010Dn\u00ED." . . "hypertension; renin-angiotensin system; endothelin; subtotal nephrectomy; ACE inhibitor; AT1 inhibitor; atrasentan; renal failure; cardiac hypertrophy; rats"@en . . . " ACE inhibitor" .