"Profylaktick\u00E1 oboustrann\u00E1 mastektomie s prim\u00E1rn\u00ED rekonstrukc\u00ED je u \u017Een s vysok\u00FDm \u017Eivotn\u00EDm rizikem vzniku heredit\u00E1rn\u00EDho karcinomu prsu (nositelky mutace BRCA, riziko vzniku karcinomu 85 %) onkologicky efektivn\u00ED alternativou, nesni\u017Euj\u00EDc\u00ED kvalitu \u017Eivota."@cs . . . "0"^^ . "3"^^ . "0"^^ . "3"^^ . "Surgical Prevention of the Breast Cancer in Patients with Hereditary Disposition"@en . "1"^^ . . . "Chirurgick\u00E1 prevence karcinomu prsu u pacientek s heredit\u00E1rn\u00ED dispozic\u00ED" . . . . . . . "breast carcinoma; prophylactic mastectomy; BRCA; breast reconstruction"@en . " prophylactic mastectomy" . "NS10401" . "2013-10-31+01:00"^^ . . . "Prophylactic bilateral mastectomy with primary reconstruction in women with the high risk of breast cancer development (BRCA +, lifetime risk of cancer 85 %) is oncological safe and effective procedure without worsening the quality of life."@en . . "http://www.isvav.cz/projectDetail.do?rowId=NS10401"^^ . "2011-12-31+01:00"^^ . . . . "Annotation I: BRCA mutation carriers have up to 85% risk to get breast carcinoma. In register of Masaryk Memorial Cancer Institute (MMCI) in Brno there are 300 patients \u2013 carriers of BRCA mutation. So far, there is no efficient prevention except of bilateral mastectomy. Annotation II: We want to offer and to perform bilateral mastectomy with immediate breast reconstruction (abdominal flap or implants) to these patients. Patient will decide, after reading detailed informed consent wether she is going to have surgery (group A) or to have cancer screening only (group B). Annotation III: Both groups will be compared regarding to l. carcinoma development 2. quality of life. In group A quality of life will be compared before and after operation. Annotation IV: Efficiency of prophylactic mastectomy will by evaluated also in group C - women that underwent prophylactic mastectomy in period 2000-2008 years."@en . "Anotace I Nositelky BRCA mutace maj\u00ED riziko a\u017E 85 %, \u017Ee dostanou karcinom prsu. V registru Masarykova onkologick\u00E9ho \u00FAstavu v Brn\u011B je kolem 300 zdrav\u00FDch nosi\u010Dek mutace BRCA. U t\u011Bchto pacientek nen\u00ED dosud zn\u00E1ma \u00FA\u010Dinn\u00E1 prevence rozvoje karcinomu krom\u011B oboustrann\u00E9 mastektomie. Anotace II Takto rizikov\u00FDm pacientk\u00E1m chceme nab\u00EDdnout a u n\u011Bkter\u00FDch prov\u00E9st oboustrannou mastektomii s okam\u017Eitou rekonstrukc\u00ED (laloky z b\u0159icha \u010Di implant\u00E1ty). Rozhodnut\u00ED k operaci provede pacientka na z\u00E1klad\u011B informovan\u00E9ho souhlasu. Anotace III Vzniknou dva soubory pacientek A - po mastektomii a rekonstrukci a B - neoperovan\u00E9. Oba soubory se prospektivn\u011B porovnaj\u00ED z hlediska v\u00FDskytu karcinomu prsu, a u souboru pacientek A se porovn\u00E1 kvalita \u017Eivota p\u0159ed a po operaci. Anotace IV Efektivnost profylaktick\u00E9 mastektomie se d\u00E1le zjist\u00ED v retrospektivn\u00ED studii v\u00FDskytu karcinomu prsu u zdrav\u00FDch nosi\u010Dek BRCA, kter\u00E9 ji\u017E podstoupily operaci v letech 2000-2008 - skupina pacientek C." . "breast carcinoma" . . "2011-08-08+02:00"^^ . "2009-01-01+01:00"^^ . " BRCA" . .