"17"^^ . "2011-08-08+02:00"^^ . . . . . "1"^^ . "S perspektivou z\u00EDsk\u00E1n\u00ED n\u00E1stroje (marker\u016F) pro exaktn\u00ED diagnostiku intraamni\u00E1ln\u00ED infekce byly nejmodern\u011Bj\u0161\u00EDmi proteomick\u00FDmi p\u0159\u00EDstupy (v\u010Detn\u011B vlastn\u00EDch) charakterizov\u00E1ny zm\u011Bny v proteomu p\u0159ed\u010Dasn\u011B ode\u0161l\u00E9 plodov\u00E9 vody v d\u016Fsledku jej\u00ED infekce."@cs . "4"^^ . "2009-01-01+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NS10382"^^ . "0"^^ . . "The intraamniotic infection is a main reason of the preterm labor and could lead to the systemic fetal inflammatory response syndrome(FIRS). FIRS is also associated with perinatal morbidity and mortality, independent of its association with premature birth. We try to use proteomics to identify the amniotic fluid protein profile characteristic of intrauterine inflammation and FIRS and we will evaluate amniotic fluid level interleukin 8 and matrix metalloproteinase 8 in patients with preterm rupture of the membranes and we will describe the difference between fetuses with and without intraamniotic infection and FIRS. At least, we try to characterize the changes in fetal blood cortisol and dehydroepiandrosterone sulphate levels for early prediction of intraamniotic infection and FIRS."@en . . "proteomic" . . "proteomic; intraamniotic infection; the fetal inflammatory respons; cytokines"@en . "NS10382" . . . . . . " intraamniotic infection" . "2013-10-31+01:00"^^ . "With a perspective to uncover marker(s) for exact diagnosis of intraamniotic infection changes in the amniotic fluid proteom associated with infection were characterized by elaborate proteomic approaches, incl. those developed by the authors themselves."@en . "Identifikace biomarker\u016F intraamni\u00E1ln\u00ED infekce a syndromu z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi plodu v plodov\u00E9 vod\u011B: proteomick\u00FD p\u0159\u00EDstup" . "Identification of biomarkers of intraamniotic inflammation and the systemic fetal response syndrome in amniotic fluid: proteomic approach"@en . "2011-12-31+01:00"^^ . . . "Mezi nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dinu p\u0159ed\u010Dasn\u00E9ho porodu pat\u0159\u00ED intraamni\u00E1ln\u00ED infekce, kter\u00E1 v n\u011Bkter\u00FDch p\u0159\u00EDpadech m\u016F\u017Ee v\u00E9st a\u017E ke vzniku syndromu fet\u00E1ln\u00ED z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi (FIRS), kter\u00FD je doprov\u00E1zen zv\u00FD\u0161en\u00EDm perinat\u00E1ln\u00ED morbidity a mortality, a to nez\u00E1visle na gesta\u010Dn\u00EDm st\u00E1\u0159\u00ED plodu. Prim\u00E1rn\u00EDm z\u00E1m\u011Brem projektu je pomoc\u00ED modern\u00EDch n\u00E1stroj\u016F proteomiky charakterizovat rozd\u00EDly mezi proteinov\u00FDm slo\u017Een\u00EDm plodov\u00E9 vody u pacientek s p\u0159ed\u010Dasn\u00FDm odtokem plodov\u00E9 vody (PPROM) s a bez intraamni\u00E1ln\u00ED infekce, \u010Di FIRS plodu. Takto identifikovan\u00E9 proteiny by v budoucnu mohly slou\u017Eit jako biomarkery pro diagnostiku intraamni\u00E1ln\u00ED infekce, \u010Di FIRS. Dal\u0161\u00EDm z\u00E1m\u011Brem je sledov\u00E1n\u00ED rozd\u00EDl\u016F v koncentrac\u00EDch IL-8 (IL-8) a matrix metalloproteinasy 8 (MMP-8) v plodov\u00E9 vod\u011B pacientek s PPROM s a bez intraamni\u00E1ln\u00ED infekce, \u010Di FIRS. Posledn\u00EDm d\u00EDl\u010D\u00EDm \u00FAkolem je ov\u011B\u0159en\u00ED je vyu\u017Eit\u00ED zm\u011Bn pom\u011Bru hladin kortizolu a DHEA-S ve fet\u00E1ln\u00ED krvi k rychl\u00E9 poporodn\u00ED diagnostice FIRS." . . " the fetal inflammatory respons" . . . . "17"^^ .