. "2009-01-01+01:00"^^ . . . "1. an analysis of 3 polymorphisms of GRM3 gene (rs2228596, rs1468412 a rs6465084) in the population of schizophrenic patients 2. correlation of above described polymorphisms with phenotype markers of schizophrenia (18FDG PET, fMRI, MRI, N-back test) 3. the influence of metabotropic glutamate receptor mGlu2/3 agonist (LY379268) on behavioral, EEG and neurotransmitter changes in pharmacological glutamatergic model of psychosis (MK-801) 4. the influence of ionotropic glutamate receptor AMAP antagonist (CNQX) on behavioral, EEG and neurotransmitter changes in pharmacological glutamatergic model of psychosis (MK-801) 5. the influence of metabotropic glutamate receptor mGlu2/3 agonist (LY379268) on behavioral, EEG and neurotransmitter changes in pharmacological serotonergic model of psychosis (2C-B) 6. the influence of ionotropic glutamate receptor AMAP antagonist (CNQX) on behavioral, EEG and neurotransmitter changes in pharmacological serotonergic model of psychosis (2C-B)"@en . " N-back test" . "Role of metabotropic mGlu2/3 a AMPA glutamatergic receptors in neurobiology of schizophrenia"@en . " MK-801" . . "2013-10-31+01:00"^^ . " GRM3" . " microdialysis" . . . "NS10375" . "2011-08-08+02:00"^^ . "10"^^ . "Analyses of polymorphisms of GRM3 gene and their correlation with phenotype markers of schizophrenia did not find any differences between healthy and patients. mGlu2/3 agonism and AMPA antagonism partially normalized changes in models of psychoses."@en . "10"^^ . "mGLU2/3" . . "0"^^ . " behavior" . " EEG" . . "Anal\u00FDzy polymorf\u00EDsm\u016F genu GRM3 a jejich korelace s fenotypov\u00FDmi markery schizofrenn\u00EDho onemocn\u011Bn\u00ED nenalezla \u017E\u00E1dn\u00E9 rozd\u00EDly mezi zdrav\u00FDmi a nemocn\u00FDmi. Agonismus mGlu2/3 i antagonismus AMPA receptor\u016F \u010D\u00E1ste\u010Dn\u011B normalizovaly zm\u011Bny v modelech psych\u00F3z."@cs . " 18FDG PET" . "1"^^ . . " 2C-B" . . " fMRI" . . " schizophrenia" . " animal model" . " genetic" . " locomotion" . " single nucleotid polymorphism" . . "0"^^ . " glutamate" . " AMPA" . . . . . "Role metabotropn\u00EDch mGlu2/3 a AMPA glutam\u00E1tergn\u00EDch receptor\u016F v neurobiologii schizofrenie" . "1. anal\u00FDza 3 polymorfism\u016F genu GRM3 (rs2228596, rs1468412 a rs6465084) v populaci schizofrenn\u00EDch pacient\u016F 2. korelace v\u00FD\u0161e popsan\u00FDch polymorfism\u016F s fenotypov\u00FDmi markery schizofrenn\u00EDho onemocn\u011Bn\u00ED (18FDG PET, fMRI, MRI, N-back test) 3. vliv agonisty metabotropn\u00EDch glutam\u00E1tov\u00FDch receptor\u016F mGlu2/3 (LY379268) na behavior\u00E1ln\u00ED, EEG a neurotrasnmiterov\u00E9 zm\u011Bny v anim\u00E1ln\u00EDm farmakologick\u00E9m glutam\u00E1tergn\u00EDm modelu psych\u00F3z (MK-801) 4. vliv antagonisty ionotropn\u00EDch glutam\u00E1tov\u00FDch AMPA receptor\u016F (CNQX) na behavior\u00E1ln\u00ED, EEG a neurotrasnmiterov\u00E9 zm\u011Bny v anim\u00E1ln\u00EDm farmakologick\u00E9m glutam\u00E1tergn\u00EDm modelu psych\u00F3z (MK-801) 5. vliv agonisty metabotropn\u00EDch glutam\u00E1tov\u00FDch receptor\u016F mGlu2/3 (LY379268) na behavior\u00E1ln\u00ED, EEG a neurotrasnmiterov\u00E9 zm\u011Bny v anim\u00E1ln\u00EDm farmakologick\u00E9m serotonergn\u00EDm modelu psych\u00F3z (2C-B) 6. vliv antagonisty ionotropn\u00EDch glutam\u00E1tov\u00FDch AMPA receptor\u016F (CNQX) na behavior\u00E1ln\u00ED, EEG a neurotrasnmiterov\u00E9 zm\u011Bny v anim\u00E1ln\u00EDm farmakologick\u00E9m serotonergn\u00EDm modelu psych\u00F3z (2C-B)" . . . . "mGLU2/3; GRM3; AMPA; glutamate; MK-801; 2C-B; single nucleotid polymorphism; genetic; schizophrenia; animal model; prefrontal cortex; behavior; MRI; fMRI; 18FDG PET; N-back test; EEG; senzorimotor gating; microdialysis; locomotion; rats"@en . . " prefrontal cortex" . " MRI" . " senzorimotor gating" . "http://www.isvav.cz/projectDetail.do?rowId=NS10375"^^ . "2011-12-31+01:00"^^ .