. "Alzheimer\u00B4s disease; cerebrospinal fluid; biomarker; neurofilament; antibody; diagnosis; tau; phosphotau; beta amyloid; neuronal cytoskeleton"@en . . . . . . "2011-08-08+02:00"^^ . . "2011-12-31+01:00"^^ . " tau" . " biomarker" . . " neurofilament" . " beta amyloid" . " cerebrospinal fluid" . "\u0158e\u0161en\u00ED projektu roz\u0161\u00ED\u0159ilo mo\u017Enosti likvorov\u00E9 diagnostiky Alzheimerovy nemoci, p\u0159ineslo zcela nov\u00E9 poznatky o humor\u00E1ln\u00ED imunit\u011B u pacient\u016F s Alzheimerovou nemoc\u00ED a p\u0159isp\u011Blo k v\u00FDvoji n\u011Bkolika nov\u00FDch ELISA metod p\u0159i detekci protil\u00E1tek proti cytoskeletu."@cs . . . "0"^^ . "Vyu\u017Eit\u00ED neurocytoskelet\u00E1ln\u00EDch protein\u016F a protil\u00E1tek proti nim v diagnostice Alzheimerovy nemoci" . . "Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer\u00B4s disease"@en . " antibody" . " diagnosis" . "1"^^ . . "V mozkom\u00ED\u0161n\u00EDm moku a s\u00E9ru pacient\u016F s AN a bez n\u00ED budou ELISA metodami stanoveny hladiny neurocytoskelet\u00E1ln\u00EDch protein\u016F (protein tau, fosfotau, lehk\u00E1 a t\u011B\u017Ek\u00E1 podjednotka neurofilamentov\u00E9ho tripletu) a sou\u010Dasn\u011B protil\u00E1tky proti nim. Hladina samotn\u00FDch protein\u016F, protil\u00E1tek proti nim a p\u0159edev\u0161\u00EDm jejich vz\u00E1jemn\u00E1 interakce mohou p\u0159isp\u011Bt k popisu odli\u0161nost\u00ED mezi patologick\u00FDm a fyziologick\u00FDm st\u00E1rnut\u00EDm mozku. V\u00FDsledkem \u0159e\u0161en\u00ED projektu by mohlo b\u00FDt zkvalitn\u011Bn\u00ED klinick\u00E9 diagnostiky AN a zji\u0161t\u011Bn\u00ED nov\u00FDch poznatk\u016F u AN z hlediska humor\u00E1ln\u00ED imunity." . "2"^^ . "Neurocytoskeletal proteins (tau and phosphotau proteins, light and heavy subunits of neurofilaments) and antibodies against them will be measured using ELISA in samples of cerebrospinal fluid and serum in patients with and without Alzheimer\u00B4s disease. Levels of neurocytoskeletal proteins themselves, antibodies against these proteins themselves and especially their mutual relationship may contribute to the differences between pathological and physiological ageing of the brain. The outcome of the project could be refining the diagnosis of AD and find new immunological aspects of AD in terms of humoral immunity."@en . "2013-10-31+01:00"^^ . . "2009-01-01+01:00"^^ . . "Alzheimer\u00B4s disease" . "NS10369" . "The project broadened the spectrum of CSF diagnostics in Alzheimer\u00B4s disease. It also brought a new data in humoral immunity in Alzheimer\u00B4s disease. Several new ELISA methods for the cytoskeletal antibodies detection were developed."@en . "http://www.isvav.cz/projectDetail.do?rowId=NS10369"^^ . " phosphotau" . . "24"^^ . . . "24"^^ . .