. "Plasma androgen levels may predict successful smoking cessation. The results are, however, different in men and women. Whereas in man successful smoking cessation is somehow related to markers of stress reaction, this relationship was absent in women."@en . "10"^^ . . . "10"^^ . "2011-12-31+01:00"^^ . "1"^^ . . . "1"^^ . "The smoking cessation and hormonal homeostasis oriented to neuroactive steroids"@en . . "Vztah kou\u0159en\u00ED a biosynt\u00E9zy steroid\u016F nen\u00ED dosud objasn\u011Bn. Provedeme metabolomickou studii u vlivu kou\u0159en\u00ED a jeho odvyk\u00E1n\u00ED na mu\u017Eskou steroidogenezu. Nikotinov\u00E9 metabolity jsou inhibitory 3?-hydroxysteroidn\u00ED oxidoredukt\u00E1zy, enzymu zahrnut\u00E9ho v synt\u00E9ze neuroaktivn\u00EDch metabolit\u016F progesteronu, d\u00E1le by mohly ovliv\u0148ovat hladiny neuroprotektivn\u00EDch a imunomodula\u010Dn\u00EDch 7?-hydroxy- metabolit\u016F DHEA a androstendiolu. Zam\u011B\u0159\u00EDme se na vliv kou\u0159en\u00ED na synt\u00E9zu t\u011Bchto steroid\u016F. Ku\u0159\u00E1ci maj\u00ED vy\u0161\u0161\u00ED hladiny DHEAS, kter\u00FD je n\u011Bkdy spojov\u00E1n s predikc\u00ED z\u00E1vislosti na nikotinu. Tak\u00E9 pom\u011Br DHEA ke kortizolu je v \u010Dasn\u00FDch f\u00E1z\u00EDch odvyk\u00E1n\u00ED kou\u0159en\u00ED d\u00E1v\u00E1n do souvislosti s predikc\u00ED relapsu. Budeme sledovat metabolismus steroid\u016F v 5en-cest\u011B. Kter\u00E9 by mohly predikovat m\u00EDru z\u00E1vislosti na nikotinu. Vyu\u017Eijeme tak\u00E9 standardizovan\u00E9 dotazn\u00EDky k odhadu korelac\u00ED psychick\u00FDch ukazatel\u016F se stavem steroidogeneze." . "Hladiny androgen\u016F a mohou predikovat \u00FAsp\u011B\u0161nost p\u0159i odvyk\u00E1n\u00ED kou\u0159en\u00ED. V\u00FDsledky jsou v\u0161ak rozd\u00EDln\u00E9 u mu\u017E\u016F a u \u017Een. Zat\u00EDmco u mu\u017E\u016F hraje roli i stresov\u00E1 reakce, u \u017Een tento vztah nebyl pozorov\u00E1n."@cs . . "0"^^ . . . "2009-01-01+01:00"^^ . . "NS10215" . . "Odvyk\u00E1n\u00ED kou\u0159en\u00ED a hormon\u00E1ln\u00ED homeost\u00E1za zam\u011B\u0159en\u00E1 na neuroaktivn\u00ED steroidy" . . . . "2011-08-08+02:00"^^ . . . "2013-10-31+01:00"^^ . . "The influence of smoking on the biosynthesis of steroids is still not fully described. We will run the metabolic analysis covering almost all known metabolic steps of the steroidogenesis. Nicotine metabolites inhibit the 3alpha-hydroxysteroid oxidoreductase, a key enzyme of the synthesis of neuroactive steroids. We shall focus on the influence of smoking on the synthesis of neuroprotective and immunomodulating 7-hydroxy-steroids. We will map the metabolism of steroids in the 5en-pathway. They may be used in prediction of the level of nicotine dependence. We shall use standardized questionnaires to judge the correlation between psychological markers and steroidogenesis state."@en . "neuroactive steroids - addicti"@en . "http://www.isvav.cz/projectDetail.do?rowId=NS10215"^^ . .