"The results of this project proved, that after the intravitreal application of cytostatics the therapeutic levels suitable for therapy of retinoblastoma were achieved. Optimal doses of cytostatics reduce the risk of toxic retinopathy."@en . . . "NR9532" . " chemoreduction" . "Local administration of cytostatics into the vitreous cavity of rabbits eyes ball via transcorneal way followed by measurement of vitreous concentration according various time schedule. Measurement of toxic effects of cytostatics on the structure of eye ball after intravitreous administration monitored by ophtalmological investigation and histopathological investigation after eye ball removal."@en . "2009-12-31+01:00"^^ . " tumor" . "2007-01-01+01:00"^^ . . "0"^^ . " chemotherapy" . "Sledov\u00E1n\u00ED dynamiky koncentrace cytostik ve sklivcov\u00E9m prostoru kr\u00E1li\u010D\u00EDho bulbu po transkorne\u00E1ln\u00ED a subkonjunktiv\u00E1ln\u00ED aplikaci" . "3"^^ . "0"^^ . . . " Etoposid" . "3"^^ . "Lok\u00E1ln\u00ED aplikace cytostatik do sklivcov\u00E9ho prostoru bulbu kr\u00E1l\u00EDka transkorne\u00E1ln\u011B a n\u00E1sledn\u00E9 sledov\u00E1n\u00ED dosa\u017Een\u00FDch koncentrac\u00ED v r\u016Fzn\u00E9m \u010Dasov\u00E9m odstupu. Sledov\u00E1n\u00ED toxick\u00E9ho vlivu cytostatik na struktury bulbu po intravitre\u00E1ln\u00ED aplikaci oftalmoskopick\u00FDm vy\u0161et\u0159en\u00EDm a v r\u00E1mci histopatologick\u00E9ho vy\u0161et\u0159en\u00ED enukleovan\u00FDch bulb\u016F." . "1"^^ . . "V\u00FDsledky \u0159e\u0161en\u00ED projektu prok\u00E1zaly, \u017Ee p\u0159i intravitre\u00E1ln\u00ED aplikaci cytostatik do bulbu byly dosa\u017Eeny terapeutick\u00E9 hodnoty vhodn\u00E9 pro aplikaci p\u0159i l\u00E9\u010Db\u011B d\u011Btsk\u00E9ho retinoblastomu. Nalezen\u00ED optim\u00E1ln\u00EDho d\u00E1vkov\u00E1n\u00ED sn\u00ED\u017E\u00ED riziko toxick\u00E9ho po\u0161kozen\u00ED s\u00EDtnice."@cs . . . "2009-12-18+01:00"^^ . . . . . "2011-04-27+02:00"^^ . "Measurement of the concentration of cytostatics in the vitreous cavity of rabbits eye ball after trancorneal and subconjunctival administration"@en . . . "retinoblastoma; chemoreduction; Carboplatin; Etoposid; tumor; chemotherapy; vitreous"@en . . . " Carboplatin" . "http://www.isvav.cz/projectDetail.do?rowId=NR9532"^^ . . "retinoblastoma" . . .