. "Angiogenesis, plasma cell kinetics, parameters of microenvironments of bone marrow and bone metabolism in monoclonal gammopathy of undetermined significance and initial phases of multiple myeloma"@en . . . . " RANKL/OPG" . "0"^^ . "The project evaluated significance of bone marrow angiogenesis, proliferative and apoptotic indices of myeloma plasmocytes, index ?/? of serum free light chains and imaging methods for the differentiation of MGUS and asymptomatic form of multiple myeloma"@en . . " plasma cell apoptosis" . "1"^^ . . . "Comparison of microvessel density and endothelial-cell proliferation inside bone marrow and serum levels of angiogenic cytokines (VEGF, HGF, bFGF, IL-17, endoglin, angiogenin and angiostatin) in MGUS, smoldering (SMM) and overt form of multiple myeloma (OMM). Analysis of propidium-iodide/CD138 index, i.e. PC-PI and annexin V-FITC/CD138 index, i.e. PC-AI and their mutual ratio, and the expression of CD40, CD45, CD19 and CD56, cyclin D-1, Bcl-2 plasmocytes in MGUS and initial phases of MM. Comparison of soluble molecules (CD138, sFas, IL-3, IL-17, TNF- , IL-6R, IGF-1) and parameters of bone metabolism (RANKL/OPG, osteopontin, ICTP, PICP, NTx a CTx) and MRI, 99mTcMIBI scan and FDG PET-CT in MGUS, SMM and OMM. Design of a panel of %22diagnostic and predictive parameters of neoplastic transformation%22 of MGUS, SMM and OMM, enriching contemporary IMWG 2003 criteria."@en . "1"^^ . "Angiogeneza, kinetika plasmocyt\u016F, parametry mikroprost\u0159ed\u00ED kostn\u00ED d\u0159en\u011B a metabolismu skeletu v diagnostice monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu a inici\u00E1ln\u00EDch st\u00E1di\u00ED mnoho\u010Detn\u00E9ho myelomu" . . "2011-04-27+02:00"^^ . "2007-01-01+01:00"^^ . "2009-12-18+01:00"^^ . " free light chains" . "MGUS; multiple myeloma; angiogenesis; plasma cell proliferation; plasma cell apoptosis; free light chains; RANKL/OPG; skeletal imaging methods"@en . . "MGUS" . "http://www.isvav.cz/projectDetail.do?rowId=NR9500"^^ . . "24"^^ . "Projekt zhodnotil v\u00FDznam vy\u0161et\u0159en\u00ED angiogeneze kostn\u00ED d\u0159en\u011B, prolifera\u010Dn\u00EDch a apoptotick\u00FDch index\u016F plazmocyt\u016F, indexu ?/? voln\u00FDch lehk\u00FDch \u0159et\u011Bzc\u016F i zobrazovac\u00EDch metod pro rozli\u0161en\u00ED MGNV a asymptomatick\u00E9 formy mnoho\u010Detn\u00E9ho myelomu."@cs . "24"^^ . . " multiple myeloma" . . . . . . "2009-12-31+01:00"^^ . "NR9500" . . . " plasma cell proliferation" . " angiogenesis" . "Srovn\u00E1n\u00ED stupn\u011B angiogenezy, proliferace endoteli\u00E1ln\u00EDch bun\u011Bk a hladin \u0159ady pro a anti-angiogenn\u00EDch cytokin\u016F u MGNV vs. asymptomatick\u00E9/doutnaj\u00EDc\u00ED (DMM) a rozvinut\u00E9 formy myelomu (RMM). Anal\u00FDza propidium-jodidov\u00E9ho a annexin-V indexu a exprese CD40, CD45, CD19 a CD56, cyklinu D1 a Bcl-2 plazmocyty u MGNV, DMM a RMM. Srovn\u00E1n\u00ED hladin solubiln\u00EDch molekul (CD138, sFas, IL-3, IL-17, IGF-1, TNF-?, IL-6R) a ukazatel\u016F kostn\u00EDho obratu (RANKL/OPG, osteokalcin, osteopontin, ICTP, NTx a CTx) a MR, 99mTcMIBI a FDG PET/CT u MGNV, DMM a RMM. Sestaven\u00ED %22panelu diagnostick\u00FDch krit\u00E9ri\u00ED a prediktivn\u00EDch/rizikov\u00FDch ukazatel\u016F%22 malign\u00ED transformace MGNV a progrese DMM a RMM, roz\u0161i\u0159uj\u00EDc\u00ED sou\u010Dasn\u00E1 diagnostick\u00E1 krit\u00E9ria IMWG 2003." .