"13"^^ . . " treatment" . "Investigator and his investigation team is fully competent in haemato-oncology and in all fileds of heamtology and oncology. The registr of these disesases under title %22ALERT%22 has been proven as fully functional system and source of data even other areas"@en . . " transplantation" . "AML; analysis; predictive; treatment; transplantation; genetics; survival; ALERT"@en . "6"^^ . . "I. Evaluation of known and newly detected prognostic factors in AML using hematologic, cytogenetic and molecular genetic methods, follow up the response to various kind of induction and consolidation treatment with special focus on hematopoietic cells transplantations. II. Keeping continuity in reporting AML patients data to ALERT database immediately after the diagnosis assignment and during the follow up; to evaluate minimal residual disease in complete remission in patients according to molecular genetic marker availability. III. Performance of statistical analysis of available prognostic factors with special focus on genetics and consolidation treatment strategy used in the group of 2000 patients entering the ALERT study within 1996-2009. IV. Utilising the analysis results on evaluation of quality of AML treatment in Czech republic and on creating of patients stratification treatment proposal according to prognostic factors with focus on transplantations and palliative treatment."@en . . "1"^^ . . " analysis" . . "Optimalizace n\u00E1kladn\u00FDch vy\u0161et\u0159ovac\u00EDch a l\u00E9\u010Debn\u00FDch postup\u016F s c\u00EDlem zv\u00FD\u0161en\u00ED efektivity l\u00E9\u010Dby a sn\u00ED\u017Een\u00ED mortality nemocn\u00FDch s AML vych\u00E1zej\u00EDc\u00ED z klinick\u00FDch a vysoce sofistikovan\u00FDch prediktivn\u00EDch dat a jejich multifaktori\u00E1ln\u00ED anal\u00FDzy v registru ALERT" . "The optimalization of expensive examination and treatment procedures aimed at the augmentation of treatment effectiveness and mortality reduction in AML patients based on clinical and high-sophisticated predictive data and its multifactorial analysis"@en . "I. Pomoc\u00ED hematologick\u00FDch, cytogenetick\u00FDch a molekul\u00E1rn\u011B genetick\u00FDch metod vy\u0161et\u0159ovat zn\u00E1m\u00E9 i nov\u011B odhalen\u00E9 prognostick\u00E9 faktory u AML, sledovat odpov\u011B\u010F na r\u016Fzn\u00E9 typy induk\u010Dn\u00ED a konzolida\u010Dn\u00ED l\u00E9\u010Dby se zvl\u00E1\u0161tn\u00EDm zam\u011B\u0159en\u00EDm na transplantace krvetvorn\u00FDch bun\u011Bk. II. Data nemocn\u00FDch s AML hl\u00E1sit p\u0159i diagn\u00F3ze a v r\u00E1mci sledov\u00E1n\u00ED do datab\u00E1ze nemocn\u00FDch s AML v \u010CR (ALERT) a udr\u017Eet kontinuitu projektu; dle dostupnosti molekul\u00E1rn\u011B genetick\u00E9ho markeru sledovat u nemocn\u00FDch v kompletn\u00ED remisi minim\u00E1ln\u00ED zbytkovou chorobu. III. Prov\u00E9st statistickou anal\u00FDzu dostupn\u00FDch prognostick\u00FDch faktor\u016F se speci\u00E1ln\u00EDm zam\u011B\u0159en\u00EDm na genetiku a pou\u017Eitou konsolida\u010Dn\u00ED l\u00E9\u010Debnou strategii na sestav\u011B cca 2000 nemocn\u00FDch hl\u00E1\u0161en\u00FDch do studie ALERT v letech 1996 - 2009. IV. V\u00FDsledky anal\u00FDz vyu\u017E\u00EDt pro hodnocen\u00ED kvality l\u00E9\u010Dby AML v \u010CR a pro vytvo\u0159en\u00ED n\u00E1vrhu stratifikace l\u00E9\u010Dby nemocn\u00FDch dle prognostick\u00FDch faktor\u016F se zvl\u00E1\u0161tn\u00EDm zam\u011B\u0159en\u00EDm na transplantace a paliativn\u00ED p\u00E9\u010Di." . "2012-01-10+01:00"^^ . . "0"^^ . . "2007-01-01+01:00"^^ . "NR9481" . . . . . . " survival" . . " predictive" . " genetics" . "http://www.isvav.cz/projectDetail.do?rowId=NR9481"^^ . "AML" . . . . . "2010-06-30+02:00"^^ . "\u0158e\u0161itel a t\u00FDm je v obl. hematol.onkol. pln\u011B kompetentn\u00ED a registr t\u011Bchto onemocn\u011Bn\u00ED pod n\u00E1zvem ALERT se osv\u011Bd\u010Dil jako pln\u011B funk\u010Dn\u00ED syst\u00E9m i zdroj dat ji\u017E v dal\u0161\u00EDch oblastech hematol. a onkol.p\u0159i hodnocen\u00ED \u010Dist\u011B klinick\u00FDch, ale i v\u011Bdeck\u00FDch v\u00FDstup\u016F."@cs . "13"^^ .