" hybridization" . " PCR" . "Use of virologic markers in the treatment and prevention of oral and oropharyngeal cancer"@en . "7"^^ . "7"^^ . "oropharynx; oral cavity; cancer; HPV; PCR; hybridization; serology; follow-up"@en . . . " serology" . . . "2009-12-18+01:00"^^ . " HPV" . . . . "Studie ov\u011B\u0159\u00ED, zda se z klinick\u00E9ho hlediska skupina pacient\u016F s HPV pozitivn\u00EDmi n\u00E1dory li\u0161\u00ED od nemocn\u00FDch s HPV negativn\u00EDmi n\u00E1dory. V\u00FDsledky studie p\u0159isp\u011Bj\u00ED k \u010Dasn\u011Bj\u0161\u00ED diagnostice p\u0159edev\u0161\u00EDm recidiv a k p\u0159esn\u011Bj\u0161\u00EDmu sledov\u00E1n\u00ED po l\u00E9\u010Db\u011B pomoc\u00ED molekul\u00E1rn\u011B biologick\u00FDch a s\u00E9rologick\u00FDch metod a t\u00EDm k prevenci recidiv. Mohou m\u00EDt vliv i na volbu optim\u00E1ln\u00ED l\u00E9\u010Debn\u00E9 metody a radikality l\u00E9\u010Dby. Zlep\u0161en\u00ED z\u00E1kladn\u00EDch ukazatel\u016F v\u00FDsledk\u016F onkologick\u00E9 l\u00E9\u010Dby je evidentn\u00EDm p\u0159\u00EDnosem z pohledu pacienta, ale i z hlediska socioekonomick\u00E9ho. Zaveden\u00ED biomarkeru pro v\u010Dasnou diagnostiku t\u011Bchto n\u00E1dor\u016F by m\u011Blo vliv i na sn\u00ED\u017Een\u00ED n\u00E1klad\u016F na l\u00E9\u010Dbu. V\u00FDsledky budou v\u00FDznamn\u00FDm p\u0159\u00EDsp\u011Bvkem k \u0159ad\u011B v\u00FDzkum\u016F zji\u0161\u0165uj\u00EDc\u00EDch mo\u017Enou roli HPV jako etiologick\u00E9ho faktoru orofarynge\u00E1ln\u00EDho a or\u00E1ln\u00EDho karcinomu. Studie t\u00E9\u017E zjist\u00ED typovou specificitu HPV v \u010Desk\u00E9 populaci, co\u017E p\u0159edstavuje cennou informaci pro p\u0159\u00EDpravu vakcinace v \u010CR. Umo\u017En\u00ED rovn\u011B\u017E vy\u010D\u00EDslit po\u010Det pacient\u016F s HPV asociovan\u00FDmi n\u00E1dory ORL oblasti v \u010CR." . "2007-01-01+01:00"^^ . "The study will verify the differences between the group of patients with HPV positive and negative oral/oropharyngeal tumors from the clinical point of view. The results of the project will contribute to earlier diagnosis especially of recurrences and more precise follow-up after treatment by means of molecular biological and serological methods. They could also influence the choice of optimal method and intensity of the treatment. Introduction of a biomarker for early diagnosis of these tumors would have substantial benefits. Results of our study will be an important contribution to the growing body of knowledge on the possible role of HPV as an etiological factor of oropharyngeal and oral cancer. The study also finds out the HPV type specific prevalence in the Czech population, which represents valuable information for the future vaccination. It also enables to specify the number of patients with HPV associated head and neck tumors in the Czech Republic."@en . . "HPV pozitivita n\u00E1dor\u016F dutiny \u00FAstn\u00ED a hltanu m\u00E1 prognostick\u00FD v\u00FDznam."@cs . "oropharynx" . " oral cavity" . . . "Vyu\u017Eit\u00ED virologick\u00FDch marker\u016F v l\u00E9\u010Db\u011B a prevenci karcinomu orofaryngu a dutiny \u00FAstn\u00ED" . . "2009-12-31+01:00"^^ . . . . . "0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NR9466"^^ . "NR9466" . . "1"^^ . "Prognostic value of HPV positivity of The Consens of The oral Cavity and he Pharynx."@en . . "2011-04-27+02:00"^^ . "1"^^ . . " cancer" .