. "NR9443" . "2007-01-01+01:00"^^ . " complications" . "Genetick\u00E1 variabilita enzym\u016F pent\u00F3zov\u00E9ho cyklu jako faktor moduluj\u00EDc\u00ED n\u00E1stup a progresi diabetick\u00E9 nefropatie" . "2009-12-31+01:00"^^ . "Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy"@en . " predisposition" . . "Auto\u0159i zjistili, \u017Ee funk\u010Dn\u00ED deficit thiaminu v d\u016Fsledku jeho omezen\u00E9 intracul\u00E1rn\u00ED dostupnosti je hlavn\u00ED abnormalitou u diabetik\u016F."@cs . "Projekt si klade za c\u00EDl pomoc\u00ED genetick\u00E9ho vy\u0161et\u0159en\u00ED variability v genech pro transketol\u00E1zu a transaldol\u00E1zu optimalizovat \u010Dasnou diagnostiku diabetick\u00E9 nefropatie a umo\u017Enit individualizaci sledov\u00E1n\u00ED diabetik\u016F a p\u0159\u00EDpadn\u011B i radik\u00E1lnosti terapie." . "diabetes" . . "11"^^ . . . "11"^^ . . . "The project aims to optimise early diagnostics of diabetic nephropathy by means of genetic analysis of transketolase and transaldolase genes and to allow individualised follow-up of diabetics and, eventually, even individualised therapeutic strategy."@en . " polymorphism" . . . . "0"^^ . "diabetes; complications; nephropathy; predisposition; prediction; polymorphism; transcetolase; glycemia"@en . "http://www.isvav.cz/projectDetail.do?rowId=NR9443"^^ . . "2011-04-27+02:00"^^ . "1"^^ . "1"^^ . "Functional thiamine deficiency due to its limited intracellular availability seems to be a dominant abnormality in diabetic patients."@en . . " nephropathy" . . . . . . " prediction" . " transcetolase" . "2009-12-18+01:00"^^ . . .