"7"^^ . "Increased risk of diabetes mellitus 2 (DM 2) and cardiovascular diseases (CVD) is associated with low birth weight and low IGF-I levels. Some polymorphism of IGF-I gene correlates with IGF-I levels, decreasing levels of IGF-I according to age and pattern of pre - and postnatal growth. The aim is to study of dynamics of changes of IGFs/IGFBPs, some of IGF-I polymorphism in children born small for gestational age (SGA/IUGR) and children with extremely low birth weight (ELBW) and correlations between IGFs, IGFBPs and IGF-I gene polymorphism with postnatal growth pattern. 50 SGA/IUGR and 50 ELBW children will be prospectively followed up for two years, at 24 months psychological examination will be performed. Blood for IGFs/IGFBPs and IGF-I gene polymorphism will be taken from umbilical cord and in regular intervals in postnatal period along with test indicated from medical reason. Control group will be formed by 200 healthy full-term newborns, only their umbilical cord will be collected."@en . . "7"^^ . "Prospektivn\u00ED studie faktor\u016F ovliv\u0148uj\u00EDc\u00EDch postnat\u00E1ln\u00ED r\u016Fst a p\u0159edstavuj\u00EDc\u00ED riziko n\u011Bkter\u00FDch chorob v dosp\u011Blosti u d\u011Bt\u00ED narozen\u00FDch s n\u00EDzkou porodn\u00ED hmotnostn\u00ED vzhledem ke gesta\u010Dn\u00EDmu v\u011Bku a d\u011Bt\u00ED s velmi n\u00EDzkou porodn\u00ED hmotnost\u00ED" . " IGF-I gene" . . . "Vy\u0161\u0161\u00ED riziko diabetes mellitus 2 (DM 2) a kardiovaskul\u00E1rn\u00EDch chorob (CVD) je spojeno s n\u00EDzkou porodn\u00ED hmotnost\u00ED a n\u00EDzk\u00FDmi hladinami IGF-I. Polymorfismy genu IGF-I koreluj\u00ED s hladinami IGF-I, poklesem IGF-I s v\u011Bkem, charakterem pre i postnat\u00E1ln\u00EDho r\u016Fstu. C\u00EDlem je studium zm\u011Bn IGFs/IGFBPs, polymorfism\u016F genu IGF-I u d\u011Bt\u00ED s n\u00EDzkou porodn\u00ED hmotnost\u00ED vzhledem ke gesta\u010Dn\u00EDmu v\u011Bku (SGA/IUGR) a d\u011Bt\u00ED s extr\u00E9mn\u011B n\u00EDzkou porodn\u00ED hmotnost\u00ED (ELBW) a vztah mezi IGFs, IGFBPs a polymorfismy genu IGF-I k charakteru r\u016Fstu. 50 d\u011Bt\u00ED s SGA/IUGR a 50 s ELBW bude prospektivn\u011B sledov\u00E1no po dobu 2 let, ve 2 letech bude provedeno psychologick\u00E9 vy\u0161et\u0159en\u00ED.Vy\u0161et\u0159en\u00ED IGFs/IGFBPs a polymorfism\u016F genu pro IGF-I bude provedeno z odb\u011Bru krve z placenty a v postnat\u00E1ln\u00EDm obdob\u00ED v r\u00E1mci odb\u011Br\u016F ze zdravotn\u00ED indikace. Kontroln\u00ED skupinu bude tvo\u0159it 200 zdrav\u00FDch dono\u0161en\u00FDch d\u011Bt\u00ED, u kter\u00FDch bude odebr\u00E1na pupe\u010Dn\u00EDkov\u00E1 krev k vy\u0161et\u0159en\u00ED polymorfism\u016F IGF-I genu, u 50 d\u011Bt\u00ED i IGFs/IGFBPs." . "2011-04-27+02:00"^^ . . . . "NR9374" . "Prospective study of factors influencing postnatal growth and factors that constitute risk of certain diseases in adulhood in children born small for gestational age and in children with extremely low birth weight"@en . . . . "2009-12-31+01:00"^^ . "low birth weight; IGF; IGFBP; diabetes mellitus 2; cardiovascular disease; postnatal growth; IGF-I gene; polymorphism"@en . " IGF" . "2007-01-01+01:00"^^ . . . . "low birth weight" . " postnatal growth" . " IGFBP" . . "Byla zji\u0161t\u011Bna distribuce polymorfism\u016F v IGF + genu u d\u011Bt\u00ED s n\u00EDzkou porodn\u00ED hmotnost\u00ED a extr\u00E9mn\u011B nezral\u00FDch."@cs . " diabetes mellitus 2" . . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR9374"^^ . . "1"^^ . "1"^^ . . . "2009-12-18+01:00"^^ . " cardiovascular disease" . "The distribution of several IGF 1 gene polymorphism in group of childern born smal and extremely premature childern were discribed."@en .