. . "2009-12-18+01:00"^^ . . . "Determination of the role of SWI/SNF complex during progression of melanoma and smal cell carcinoma of the lung."@en . . . "NR9319" . . " NSCLC" . " SWI/SNF" . " melanoma" . . "Multiproteinov\u00FD chromatin-remodeluj\u00EDc\u00ED komplex SWI/SNF je pova\u017Eov\u00E1n za n\u00E1dorov\u00FD supresor a jeho funkce je u n\u011Bkolika typ\u016F n\u00E1dorov\u00FDch bun\u011Bk poru\u0161ena t\u00EDm, \u017Ee n\u011Bkter\u00E9 jeho slo\u017Eky (Brm, Brg1 a INI1) jsou deletov\u00E1ny nebo mutov\u00E1ny. Bude zkoum\u00E1na exprese komponent komplexu v bu\u0148k\u00E1ch malobun\u011B\u010Dn\u00E9ho (SCLC) i nemalobun\u011B\u010Dn\u00E9ho (NSCLC) karcinomu plic a malign\u00EDho melanomu a vztah exprese k n\u00E1dorov\u00E9 progresi. D\u00E1le bude zkoum\u00E1na \u00FAloha tohoto komplexu p\u0159i transkripci gen\u016F a marker\u016F spojen\u00FDch s diferenciac\u00ED melanomov\u00FDch bun\u011Bk. V\u00FDsledky uk\u00E1\u017E\u00ED na mo\u017Enou \u00FAlohu poru\u0161en\u00E9ho komplexu p\u0159i patogenezi t\u011Bchto n\u00E1dor\u016F zejm\u00E9na ve vztahu k invazivit\u011B a metastasov\u00E1n\u00ED a pomohou p\u0159i prognose n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED." . . " Brg1" . "transcription" . . . . "Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma"@en . "Poruchy funkce a slo\u017Een\u00ED chromatin-remodeluj\u00EDc\u00EDho komplexu SWI/SNF v n\u00E1dorov\u00E9 progresi karcinomu plic a melanomu" . . "1"^^ . "1"^^ . " SCLC" . "2007-01-01+01:00"^^ . " Brm" . "3"^^ . . "3"^^ . . "Objasn\u011Bn\u00ED role komplexu SWI/SNF p\u0159i progresi resp. r\u016Fstu melanomu a malobun\u011B\u010Dn\u00E9ho karcinomu plic"@cs . . "0"^^ . "2009-12-31+01:00"^^ . "The SWI/SNF chromatin-remodeling complex functions as a tumor suppressor and several of its subunits (Brm, Brg1 a INI1) were found to be mutated in human tumors. We propose to study the expression of the SWI/SNF components in non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and melanoma, and to investigate the role of an abrogated function of SWI/SNF in the progression of these three specific tumor types. We will further study how SWI/SNF participates in the differentiation program of melanoma cells. The results will indicate how the altered function or loss of subunits contribute to malignant behavior of the selected types of tumors with respect to invasion and formation of metastases."@en . "http://www.isvav.cz/projectDetail.do?rowId=NR9319"^^ . . "transcription; SWI/SNF; SCLC; NSCLC; melanoma; Brm; Brg1; Akt"@en . "2011-04-27+02:00"^^ . .