"2011-04-27+02:00"^^ . " genetic" . "1"^^ . . "ADHD" . "1"^^ . "Annotation: Further to the results of the project IGA MZ CR 6520-5 of the years 2000-2005, the variants of ADHD course will be monitored within a longitudinal study in 100 boys which had an exactly diagnosed subtype of the disorder in childhood and their genotype was determined. A new examination of the probands during adolescence and at the beginning of adulthood will enable to detect individuals with the persistent form of ADHD and individuals without any symptoms. A correlation between the course of ADHD and clinical and biological markers of the disease (a subtype of the disorder, heredity, perinatal insults, reactivity to medication and with the genome DNA analysis results) will be searched using a comparison with the original clinical and laboratory data in the database."@en . . "Risk factors in persistent form of hyperkinetic disorder(ADHD) .Longitudinal, clinic and molecular-genetic study."@en . . "0"^^ . "Nejpodstatn\u011Bj\u0161\u00EDm v\u00FDsledkem projektu je prohlouben\u00ED poznatk\u016F o etiopatogenesi ADHD u d\u011Bt\u00ED a persistenci t\u00E9to poruchy do dosp\u011Blosti."@cs . . . . . . " longitudinal" . "ADHD; adolescents; genetic; persistent; longitudinal; study"@en . . . "2008-03-05+01:00"^^ . . "Rizikov\u00E9 faktory u perzistentn\u00ED formy hyperkinetick\u00E9 poruchy(ADHD).Longitudin\u00E1ln\u00ED,klinick\u00E1 a molekul\u00E1rn\u011B-genetick\u00E1 studie." . " persistent" . . "http://www.isvav.cz/projectDetail.do?rowId=NR9298"^^ . . "2007-01-01+01:00"^^ . . "Na z\u00E1klad\u011B rozhodnut\u00ED VR byl projekt k 31.12.2008 zastaven."@cs . "24"^^ . "24"^^ . " adolescents" . . . "NR9298" . "Essentials result of the project is the deeper knowledge od children's etiopatogenesis ADHD and its persistence up to adult age."@en . . "Following the decision of VR projekt was halted as of 21. 12. 2008."@en . . "Anotace : V n\u00E1vaznosti na v\u00FDsledky projektu IGA MZ \u010CR 6520-5 z let 2000-2005 , budou v r\u00E1mci longitudin\u00E1ln\u00ED studie sledov\u00E1ny pr\u016Fb\u011Bhov\u00E9 varianty hyperkinetick\u00E9 poruchy u 100 chlapc\u016F , u nich\u017E byl v d\u011Btstv\u00ED, p\u0159i \u0159e\u0161en\u00ED p\u016Fvodn\u00EDho projektu, klinick\u00FDm a psychologick\u00FDm laboratorn\u00EDm vy\u0161et\u0159en\u00EDm, p\u0159esn\u011B ur\u010Den subtyp poruchy ( podle MKN 10 a podle DSM IV) a vy\u0161et\u0159en\u00EDm genomick\u00E9 DNA z\u00EDsk\u00E1n jejich individu\u00E1ln\u00ED genotyp. Nov\u00E9 vy\u0161et\u0159en\u00ED proband\u016F b\u011Bhem adolescence a na prahu dosp\u011Blosti, umo\u017En\u00ED detekovat jedince s perzistuj\u00EDc\u00ED formou hyperkinetick\u00E9 poruchy a jedince bez p\u0159\u00EDznak\u016F. Srovn\u00E1n\u00EDm s p\u016Fvodn\u00EDmi klinick\u00FDmi a laboratorn\u00EDmi \u00FAdaji ulo\u017Een\u00FDmi v datab\u00E1zi, bude provedena korelace pr\u016Fb\u011Bhov\u00FDch variant hyperkinetick\u00E9 poruchy (remituj\u00EDc\u00ED a perzistuj\u00EDc\u00ED) s klinick\u00FDmi a biologick\u00FDmi markery onemocn\u011Bn\u00ED ( se subtypem poruchy, hereditou, perinat\u00E1ln\u00EDmi vlivy, reakc\u00ED na farmakoterapii, a s v\u00FDsledky anal\u00FDzy genomov\u00E9 DNA.)" .