" lymphocytes" . "2009-12-18+01:00"^^ . . . " reconstitution" . . . . "Monitorace anti- CMV specifick\u00E9 imunitn\u00ED odpov\u011Bdi u pacient\u016F po alogenn\u00ED transplantaci hemopoetick\u00FDch progenitorov\u00FDch bun\u011Bk a po transplantaci ledviny" . . "cytomegalovirus; tetramers; reconstitution; lymphocytes; transplantation"@en . "2007-01-01+01:00"^^ . "Monitoring of CMV- specific immune reconstitution in patients after hematopoietic stem cell transplantation and after kidney transplantation"@en . . . "NR9267" . "Sledov\u00E1n\u00ED anti-CMV cytotoxick\u00FDch T-lymfocyt\u016F metodikou HLA tetrametr\u016F je cennou metodou v monitoraci nemocn\u00FDch po transplantaci. Po\u010Det t\u011Bchto bun\u011Bk pod 10/ul zvy\u0161uje nebezpe\u010D\u00ED klinick\u00E9 CMV infekce a m\u016F\u017Ee indikovat pre-emptivn\u00ED anti-CMV l\u00E9\u010Dbu."@cs . " tetramers" . . . . "1. Monitorov\u00E1n\u00ED anti- CMV specifick\u00E9 bun\u011B\u010Dn\u00E9 imunity u pacient\u016F po transplantaci hemopoetick\u00FDch progenitorov\u00FDch bun\u011Bk a transplantaci ledviny pomoc\u00ED tetramer technologie a pr\u016Ftokov\u00E9 cytometrie. 2. Zji\u0161t\u011Bn\u00ED korelace mezi frekvenc\u00ED anti- CMV specifick\u00FDch T- lymfocyt\u016F a v\u00FDskytem CMV reaktivace. Stanoven\u00ED prediktivn\u00ED hladiny, kter\u00E1 je spojena s vysok\u00FDm rizikem CMV reaktivace. 3. Posouzen\u00ED vlivu CMV profylaxe a vir\u00E9mie na dynamiku rekonstituce a v\u00FDskyt pozdn\u00ED CMV infekce. Porovn\u00E1n\u00ED kinetiky anti-CMV specifick\u00E9 imunitn\u00ED odpov\u011Bdi s ohledem na CMV s\u00E9rologick\u00FD status d\u00E1rce u transplantac\u00ED hemopoet. kmenov\u00FDch bun\u011Bk. 4. \u00DAprava postup\u016F p\u0159i rozhodov\u00E1n\u00ED o zah\u00E1jen\u00ED protivirov\u00E9 l\u00E9\u010Dby s c\u00EDlem l\u00E9\u010Dit pouze vysoce rizikov\u00E9 nemocn\u00E9 a nezat\u011B\u017Eovat virostatiky pacienty s dostate\u010Dnou anti- CMV imunitou." . . . "cytomegalovirus" . . "1"^^ . . . "3"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR9267"^^ . "0"^^ . "3"^^ . "2011-04-27+02:00"^^ . . "0"^^ . . "2009-12-31+01:00"^^ . . "1. Monitoring of anti-CMV specific cellular immunity in patients after hemopoietic stem cell transplantation and after kidney transplantation using tetramer technology and flow cytometry. 2. Survey of correlation between the frequency of anti-CMV specific T- lymphocytes and the occurrence of CMV reactivation. Determination of predictive level associated with increased risk of CMV reactivation. 3. Evaluation of the influence of CMV profylaxis and CMV viremia on kinetics of immune reconstitution and on late CMV infection occurrence. Association of hemopoietic stem cells donor/recipient CMV serological status with kinetics of anti- CMV specific immune response. 4. Modification of antiviral treatment guidelines: firstly treat the high risk patients group and postpone the treatment in patients with satisfactory immunity to avoid the antiviral medications adverse effect."@en . "Monitoring of anti-CMV cytotoxic T-cells by the HLA tetramer method is a valuable approach in monitoring patients after transplantation. The risk of the CVM disease is increased if the cells are <10/ul, which may indicate pre-emptive anti-CMV treatment"@en . .