"Anotace I: Prospektivn\u00ED klinick\u00E1 studie vz\u00E1jemn\u00E9 vazby a \u00FAlohy z\u00E1kladn\u00EDch aterogenn\u00EDch mechanism\u016F p\u0159i n\u00E1hrad\u011B ren\u00E1ln\u00EDch funkc\u00ED (hemodial\u00FDza, peritone\u00E1ln\u00ED dial\u00FDza). Anotace 2: Projekt bude studovat aterogenn\u00ED v\u00FDznam, zm\u011Bny, vz\u00E1jemnou korelaci a mo\u017Enosti ovlivn\u011Bn\u00ED i) biosynt\u00E9zy a absorpce cholesterolu a jeho intermedi\u00E1rn\u00EDch produkt\u016F,, ii) stupn\u011B lipoperoxidace, iii) konsumpce antioxidant\u016F, iv) endoteli\u00E1ln\u00ED dysfunkce. Anotace 3: Z\u00E1v\u011Br\u016F projektu bude vyu\u017Eito v klinick\u00E9 praxi s c\u00EDlem \u010Dasn\u00E9 identifikace a optim\u00E1ln\u00ED l\u00E9\u010Debn\u00E9 strategie pokro\u010Dil\u00E9 ateroskler\u00F3zy p\u0159i n\u00E1hrad\u011B ren\u00E1ln\u00EDch funkc\u00ED, kter\u00E1 je hlavn\u00ED p\u0159\u00ED\u010Dinou mortality a morbidity uremick\u00FDch pacient\u016F v \u010Cesk\u00E9 republice." . " cholesterol" . . "Morbidita a mortalita hemodialyzovan\u00FDch nemocn\u00FDch koreluje s faktory malnutrice, inflamace, kalcifikace a aterosklerozy. Je nezbytn\u00E1 jejich d\u016Fsledn\u00E1 kontrola a l\u00E9\u010Dba k prevenci kardiovaskul\u00E1rn\u00EDch komplikac\u00ED"@cs . "2009-12-18+01:00"^^ . . . "Atherosclerosis; hyperlipidemia; cholesterol; microinflammation; renal replacement therapy; endothelial dysfunction; oxidative stress"@en . "13"^^ . "13"^^ . " endothelial dysfunction" . "Annotation I: Prospective clinical study of the mutual interactions and particular role of fundamental atherogenic mechanisms in renal replacement therapy (hemodialysis, peritoneal dialysis). Annotation II: Project will investigate changes, correlation and possible influencing of the i) cholesterol biosynthetic pathway and its intermediary products, ii) lipoperoxidation processes, iii) antioxidant consumption, iv) endothelial dysfunction. Annotation III: The results might improve our knowledge and thus treatment of advanced atherosclerosis in renal replacement therapy, which is the leading cause of its morbidity and mortality of uremic patients in Czech Republic."@en . . . . " hyperlipidemia" . . . " microinflammation" . "2011-04-27+02:00"^^ . . "1"^^ . . . . . "0"^^ . "ATHEROGENIC MECHANISMS IN RENAL REPLACEMENT THERAPY"@en . "0"^^ . "2009-12-31+01:00"^^ . . . . "http://www.isvav.cz/projectDetail.do?rowId=NR9259"^^ . " renal replacement therapy" . "Morbidity and mortaliaty of hemodialyzed patients correlate with malnutrition, inflamation, calcicfication and athresclerosis factor. To prevent cardiovscular complications only thourogh control and adequate treatment is necessiate"@en . . "Atherosclerosis" . "MECHANISMY ATEROGENEZE P\u0158I N\u00C1HRAD\u011A REN\u00C1LN\u00CDCH FUNKC\u00CD" . "2007-01-01+01:00"^^ . "NR9259" . .