"Compliance l\u00E9\u010Dby azathioprinem u d\u011Bt\u00ED a dosp\u00EDvaj\u00EDc\u00EDch s nespecifick\u00FDmi st\u0159evn\u00EDmi z\u00E1n\u011Bty." . . " Adolescents" . . . "2009-12-18+01:00"^^ . "Na z\u00E1klad\u011B farmakokinetick\u00FDch dat p\u0159edlo\u017Een n\u00E1vrh na odli\u0161en\u00ED non-compliance od selh\u00E1n\u00ED l\u00E9\u010Dby azathioprinem u d\u011Bt\u00ED s nespecifick\u00FDm st\u0159evn\u00EDm z\u00E1n\u011Btem."@cs . . . . "NR9255" . "Description of pharmacokinetics and clinical compliance aspects of azathtioprin treatment in pediatric inflammatory bowel disease"@en . . "http://www.isvav.cz/projectDetail.do?rowId=NR9255"^^ . " Ulcerative colitis" . " Compliance" . . "Compliance of azathioprine treatment in children and adolescents with inflammatory bowel disease."@en . . "4"^^ . "Crohn disease" . "2011-04-27+02:00"^^ . "4"^^ . . . "1"^^ . " children" . "2009-12-31+01:00"^^ . " Azathioprine" . "1"^^ . . . . "Odhaduje se, \u017Ee a\u017E u 20% dosp\u00EDvaj\u00EDc\u00EDch je selh\u00E1n\u00ED imunosupresivn\u00ED l\u00E9\u010Dby nespecifick\u00FDch st\u0159evn\u00EDch z\u00E1n\u011Bt\u016F (IBD) d\u016Fsledkem non-compliance, ale validn\u00ED data nejsou v literatu\u0159e zn\u00E1ma.Azathioprin (AZT) je z\u00E1kladn\u00EDm stavebn\u00EDm kamenem imunosupresivn\u00ED l\u00E9\u010Dby d\u011Btsk\u00FDch IBD a n\u00E1stup jeho \u00FA\u010Dinku v\u00FDznamn\u011B z\u00E1vis\u00ED na inter- a intraindividu\u00E1ln\u00ED variabilit\u011B kumulace jeho metabolit\u016F. Prodleva do klinicky evidentn\u00EDho n\u00E1stupu \u00FA\u010Dinku nav\u00EDc zv\u00FDraz\u0148uje mo\u017Enost pacientovy non-compliance. Odli\u0161en\u00ED skute\u010Dn\u00E9ho selh\u00E1n\u00ED l\u00E9\u010Dby od non-compliance je mo\u017En\u00E9 prost\u0159ednictv\u00EDm anal\u00FDzy metabolismu AZT. P\u0159edev\u0161\u00EDm je d\u016Fle\u017Eit\u00FD vztah mezi aktivitou thiopurinmethyltransfer\u00E1zy, hladinou 6-methylmerkaptopurinov\u00FDch metabolit\u016F a koncentrac\u00ED nukleotid\u016F 6-thioguaninu v korelaci s klinick\u00FDm a laboratorn\u00EDm vy\u0161et\u0159en\u00EDm a s p\u0159ihl\u00E9dnut\u00EDm k mo\u017En\u00FDm ne\u017E\u00E1douc\u00EDm \u00FA\u010Dink\u016Fm l\u00E9\u010Dby. Verifikace non-compliance AZT je z\u00E1sadn\u00EDm krokem p\u0159ed rozhodnut\u00EDm o zm\u011Bn\u011B terapie." . . "Crohn disease; Ulcerative colitis; Azathioprine; Compliance; children; Adolescents; IBD"@en . . "0"^^ . . "Azathioprine (AZT) is frequently used for the therapy of inflammatory bowel disease in children. The measurement of concentrations of metabolites of 6-MP unmasks %22failure of treatment%22 by non-compliance of patient. The literary data are controversial in evidence of associations between activity of thiopurinemethyltransferase (TPMT), concentrations of metabolites of 6-MP, efficacy of the therapy and side effects of AZT in children. Principal aim: Distinguishing between non-compliance and failure of treatment during azathioprine therapy."@en . "2007-01-01+01:00"^^ . .