"2009-12-31+01:00"^^ . . " DNA vaccine" . "Tumor; Cervical carcinoma; IGFBP-3; TGF beta RII; FAP; DNA vaccine; Vaccinia virus; HPV16-E7"@en . . "Tumor" . "V\u00FDsledky \u0159e\u0161en\u00ED projektu vedly k objasn\u011Bn\u00ED n\u011Bkter\u00FDch d\u016Fle\u017Eit\u00FDch mechanism\u016F \u00FA\u010Dinnosti terapeutick\u00FDch genetick\u00FDch vakc\u00EDn nam\u00ED\u0159en\u00FDch na dominantn\u00ED antigeny n\u00E1dorov\u00FDch bun\u011Bk."@cs . . "0"^^ . . "2"^^ . "2007-01-01+01:00"^^ . "0"^^ . "2"^^ . "1"^^ . " FAP" . . . . "Vektory pro genovou terapii zac\u00EDlenou na bu\u0148ky stromatu pevn\u00FDch n\u00E1dor\u016F" . "2011-04-27+02:00"^^ . . . "The results of the project clarified important mechanisms of effectiveness of therapeutic genetic vaccines against dominat antigens of tumor cells."@en . . "http://www.isvav.cz/projectDetail.do?rowId=NR9238"^^ . " IGFBP-3" . "V\u00FDzkum terapeutick\u00E9 protin\u00E1dorov\u00E9 DNA vakc\u00EDny a vektor\u016F pro genovou terapii zam\u011B\u0159en\u00FDch na n\u00E1dorov\u00E9 fibroblasty na my\u0161\u00EDm modelu n\u00E1dor\u016F vyvolan\u00FDch papilomavirem HPV16. DNA vakc\u00EDna bude nam\u00ED\u0159ena proti fibroblastov\u00E9mu aktiva\u010Dn\u00EDmu proteinu (FAP). Vakc\u00EDna bude pod\u00E1v\u00E1na v kombinaci s vakc\u00EDnou specifickou pro onkoprotein HPV16-E7. Virov\u00E9 vektory z viru vakcinie budou v n\u00E1dorech produkovat ektodom\u00E9nu receptoru lidsk\u00E9ho TGF-beta typu II, geneticky f\u00FAzovanou k Fc fragmentu IgG1 nebo IGFBP-3 (IGF Binding Protein-3). Kombinovan\u00E1 terapie zahrnuj\u00EDc\u00ED DNA imunizaci a lok\u00E1ln\u00ED infekci virov\u00FDmi vektory, je\u017E exprimuj\u00ED blokuj\u00EDc\u00ED faktory a cytokiny zvy\u0161uj\u00EDc\u00ED imunitn\u00ED odpov\u011B\u010F, \u010D\u00EDm\u017E budou pos\u00EDleny protin\u00E1dorov\u00E9 mechanismy, ani\u017E by jednotliv\u00E9 z\u00E1sahy interferovaly." . . " Vaccinia virus" . "2009-12-18+01:00"^^ . "NR9238" . . " Cervical carcinoma" . . . " TGF beta RII" . "Investigation of an anti-tumor therapeutic DNA vaccine and vectors for gene therapy targeting tumor fibroblasts in mouse model of tumors induced by papilloma virus HPV16. DNA vaccine will provide immunization against fibroblast activating protein (FAP). Vaccine will be combined with DNA vaccine specific for viral oncoprotein HPV16-E7. Recombinant vaccinia virus vectors will allow expression of the ectodomain of the human type II TGF-beta receptor genetically fused to the IgG1Fc fragment or the gene for IGFBP-3 (IGF Binding Protein-3). Immunotherapy with DNA vaccines and viral vectors expressing the anti-tumor factors and immune response enhancing cytokines resulting in increase of the anti-tumor mechanisms."@en . . . . . "Vectors for gene therapy targeted on stromal cells of solid tumors"@en . . .