. "Periopera\u010Dn\u00ED genomika je zam\u011B\u0159ena na hled\u00E1n\u00ED genetick\u00FDch determinant, kter\u00E9 ur\u010Duj\u00ED zv\u00FD\u0161en\u00E9 riziko poopera\u010Dn\u00EDch komplikac\u00ED. Jedn\u00EDm z rizikov\u00FDch faktor\u016F je genov\u00FD polymorfismus \u010Dasn\u00FDch cytokin\u016F, kter\u00E9 hraj\u00ED kl\u00ED\u010Dovou \u00FAlohu v iniciaci a delokalizaci z\u00E1n\u011Btu. C\u00EDlem navrhovan\u00E9 klinick\u00E9 studie je zhodnocen\u00ED klinick\u00E9ho v\u00FDznamu genov\u00E9ho polymorfismu vybran\u00FDch z\u00E1n\u011Btliv\u00FDch medi\u00E1tor\u016F (TNF?, IL-1\u00DF, IL-6, IL-8, IL-10, CRP) v \u010Dasn\u00E9m poopera\u010Dn\u00EDm obdob\u00ED po rozs\u00E1hl\u00FDch nitrob\u0159i\u0161n\u00EDch v\u00FDkonech a ve vztahu k poopera\u010Dn\u00ED sepsi. Genov\u00FD profil vybran\u00FDch marker\u016F humor\u00E1ln\u00ED odpov\u011Bdi na opera\u010Dn\u00ED stres m\u016F\u017Ee b\u00FDt pro klinika formulov\u00E1n do podoby dal\u0161\u00EDho parametru pro ur\u010Den\u00ED opera\u010Dn\u00EDho rizika. Vyu\u017Eit\u00ED t\u00E9to anal\u00FDzy u rizikov\u00FDch chirurgick\u00FDch pacient\u016F umo\u017En\u00ED klinikovi individu\u00E1ln\u011B zv\u00E1\u017Eit vhodnost rozs\u00E1hl\u00E9ho radik\u00E1ln\u00EDho chirurgick\u00E9ho v\u00FDkonu s ohledem na riziko z\u00E1va\u017En\u00FDch poopera\u010Dn\u00EDch komplikac\u00ED." . . . "perioperative genomics; cytokines; gene polymorphism; postoperative sepsis; interleukin-6"@en . "http://www.isvav.cz/projectDetail.do?rowId=NR9223"^^ . "Gene polymorphism of pro and antiinflammatory cytokines has significant influence on postoperative course and is a marker of postoperative septic complications."@en . . . "2009-12-31+01:00"^^ . "NR9223" . "Projekt splnil vyt\u00FD\u010Den\u00E9 c\u00EDle - genov\u00FD polymorfismus pro a protiz\u00E1n\u011Btliv\u00FDch cytokin\u016F ovliv\u0148uje fyziologick\u00E9 tk\u00E1\u0148ov\u00E9 reakce na opera\u010Dn\u00ED trauma a v\u00FDskyt poopera\u010Dn\u00EDch septrick\u00FDch komplikac\u00ED.Je prognostick\u00FDm faktorem poopera\u010Dn\u00EDho pr\u016Fb\u011Bhu."@cs . . "0"^^ . . "0"^^ . "2009-12-18+01:00"^^ . "Perioperative genomics is aimed to both genetic and molecular determinants of a perioperative risk. One of the potential risk factors is a gene polymorphism of early cytokines, which take key part in the initialization, and delocalization of inflammation. The aim of the clinical study is to evaluate clinical significance of gene polymorphism of chosen inflammatory mediators (TNF?, IL-1\u00DF, IL-6, IL-8, IL-10, CRP) in the early postoperative period after large abdominal surgery and in postoperative sepsis. Gene profile of selected markers of humoral response to the surgical stress can be transformed to a single parameter which can be used by a physician for determining the operating risk. It will allow assessing the appropriateness of the extensive radical surgical operation in respect to the possibility of severe postoperative complications."@en . "1"^^ . . "2011-04-27+02:00"^^ . . "6"^^ . "6"^^ . " postoperative sepsis" . " cytokines" . . . . "The gene polymorphism of inflammatory cytokines as a risk factor of postoperative complications"@en . "perioperative genomics" . "Genov\u00FD polymorfismus z\u00E1n\u011Btliv\u00FDch cytokin\u016F jako rizikov\u00FD faktor poopera\u010Dn\u00EDch komplikac\u00ED" . . . . . . "2007-01-01+01:00"^^ . " gene polymorphism" . .