"type 2 diabetes" . . "2009-12-18+01:00"^^ . "Budeme aplikovat n\u00E1lezy zm\u011Bn morfologie mitochondri\u00ED u beta bu\u0148ek pankreatu, kostern\u00EDch sval\u016F a srdce u diabetick\u00FDch potkann\u00EDch model\u016F a bu\u0148. lini\u00ED za \u00FA\u010Delem v\u00FDvoje budouc\u00ED diagnostiky \u010Dasn\u00FDch stadi\u00ED diabetu 2. typu. Prov\u011B\u0159\u00EDme obdobnou diagnostiku Langerhansov\u00FDch ostr\u016Fvk\u016F pro budouc\u00ED test jejich kvality p\u0159ed transplantac\u00ED. Morfologie bude studov\u00E1na konfok\u00E1ln\u00ED a elektronovou mikroskopi\u00ED Exp. modely zahrnou: bioptick\u00E9 vzorky chirurgick\u00FDch pacient\u016F; potkan\u00ED kardiomyoblasty, a insulinomovu linii INS1E; izolovan\u00E9 potkann\u00ED Langerhansovy ostr\u016Fvky a Zuckerovy diabetick\u00E9 ob\u00E9zn\u00ED potkany a potkany kmene Goto-Kakizaki." . "Type 2 diabetes pathology is reflected in to dezintegration of mitochondrial network in beta-cells of Langerhans is lets, vizualized by 3D high resolution 4Pi microscopy combined with lentriviral transfection of matrix-addressed GFP."@en . . "NR9183" . . . . " oxidative stress" . . "We will use the knowledge of morphological changes of mitochondria of pancreatic beta cells, skeletal muscle, and heart in rat diabetic models and corresponding cell lines to develop a future diagnostics of early type 2 diabetes. We shall evaluate possibilities of similar diagnostics for Langerhans islets for a possible future tests of their quality prior to transplantation. Morphology will be studied by confocal and electron microscopy. Exp. models will involve skeletal muscle biopsies of patients skeduled for operations, rat insulinoma INS-E cells; rat cardiomyoblasts, isolated rat Langerhans islets, Zucker diabetic fatty and Goto-Kakizaki rats."@en . . " early diagnostics" . . "Mitochondrial morphology a its changes in diabetes"@en . "Dynamika mitochondri\u00E1ln\u00ED morfologie a jej\u00ED zm\u011Bny v pr\u016Fb\u011Bhu diabetu" . . "Patogeneze diabetu 2. typu se odr\u00E1\u017E\u00ED v dezintegraci mitochondri\u00E1ln\u00ED s\u00EDt\u011B v beta bu\u0148k\u00E1ch Langerhansov\u00FDch ostr\u016Fvk\u016F, vizulalizovan\u00FDch pomoc\u00ED 3D 4Pi mikroskopie s vysok\u00FDm rozli\u0161en\u00EDm s vyu\u017Eit\u00EDm lentivirov\u00E9 transfekce GFP adresovan\u00E9ho do matrix."@cs . . " Langerhans islets" . " rat models of diabetes" . "2007-01-01+01:00"^^ . . "type 2 diabetes; early diagnostics; mitochondrial morphology; oxidative stress; Langerhans islets; rat models of diabetes; confocal microscopy; electron microscopy"@en . . . . "http://www.isvav.cz/projectDetail.do?rowId=NR9183"^^ . " confocal microscopy" . . "4"^^ . "4"^^ . . "1"^^ . . "1"^^ . "2009-12-31+01:00"^^ . . . " mitochondrial morphology" . "2011-04-27+02:00"^^ . "0"^^ . .