. . . " Gene" . "2007-01-01+01:00"^^ . . " Cardiomyopathy" . "Hypertrophic; Cardiomyopathy; Gene; ECG; Holter; Arrhytmia"@en . . "Klinick\u00E9 a funk\u010Dn\u00ED korel\u00E1ty u hypertrofick\u00E9 kardiomyopatie v \u010Desk\u00E9 populaci" . "2011-04-27+02:00"^^ . . . "P\u0159edm\u011Btem na\u0161eho projektu je zjistit procentu\u00E1ln\u00ED zastoupen\u00ED 4 nej\u010Dast\u011Bji mutovan\u00FDch gen\u016F pro HKMP v \u010Desk\u00E9 populaci, sledovat jejich klinick\u00E9 a funk\u010Dn\u00ED korel\u00E1ty a zjistit v\u00FDskyt supraventrikul\u00E1rn\u00EDch a komorov\u00FDch arytmi\u00ED v z\u00E1vislosti na posti\u017Een\u00E9m genu. Genetick\u00E9mu testov\u00E1n\u00ED bude podrobeno 100 nemocn\u00FDch s HKMP a 50 zdrav\u00FDch dobrovoln\u00EDk\u016F. Jejich DNA bude v gen. laborato\u0159i vy\u0161et\u0159ena na p\u0159\u00EDtomnost mutac\u00ED ve v\u0161ech exonech gen\u016F MYH7, MYBPC3, TNN2 a TNN3. U v\u0161ech bude provedena holterovsk\u00E1 monitorace EKG. Stanoven\u00ED frekvence v\u00FDskytu \u010Dty\u0159 nej\u010Dast\u011Bji mutovan\u00FDch gen\u016F pro HKMP v \u010Desk\u00E9 populaci n\u00E1m umo\u017En\u00ED zav\u00E9st nov\u00E9 \u00FA\u010Dinn\u00E9 preventivn\u00ED, respektive terapeutick\u00E1 opat\u0159en\u00ED, za \u00FA\u010Delem zlep\u0161en\u00ED kvality a d\u00E9lky \u017Eivota jak u nemocn\u00FDch s HKMP tak i u jejich p\u0159\u00EDbuzn\u00FDch." . . . . . "An objective of our project is to find out the frequency of four major genes responsible for HCMP in Czech population, to observe theirs clinical and functional correlates and to find out the frequency of occurrence of arrhythmia due to affected gene. We will do genetic testing in 100 patients with HCMP and 50 healthy volunteers. Their DNA will be screened for mutations in all exons of genes MYH7, MYBPC3, TNN2 and TNN3. All participants of the study will also undergo 24 - hour holter ECG monitoring. Setting the frequency of the four most often affected genes for HCMP in the Czech population will make introduction of new effective preventive, respectively therapeutic measures to enable improving life quality in patients with HCMP and their relatives."@en . . . "V\u00FDskyt mutac\u00ED hlavn\u00EDch gen\u016F typick\u00FDch pro hypertrofickou kardiomyopatii v \u010Cesk\u00E9 republice."@cs . "0"^^ . "2009-12-31+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NR9164"^^ . "1"^^ . "3"^^ . " ECG" . "Hypertrophic" . "2009-12-18+01:00"^^ . . . . "11"^^ . "11"^^ . "NR9164" . . "Clinical and functional correlates of hypertrophic cardiomyopathy in Czech population"@en . " Holter" . "Incidence of four main genes mutations representative of hypertrophic obstructive cardiomyopathy in Czech Republic."@en . .