. " cyclin D1" . "2008-03-05+01:00"^^ . . " ZNF217" . . "2008-12-31+01:00"^^ . "Germline mutations of PML gene in patients with cancer"@en . . "http://www.isvav.cz/projectDetail.do?rowId=NR9092"^^ . "PML; gene; germline; mutation; cyclin D1; ZNF217; amplification; cancer"@en . . "PML" . " amplification" . . . . . . "2006-01-01+01:00"^^ . "Z\u00E1rode\u010Dn\u00E9 mutace genu PML u pacient\u016F s n\u00E1dorov\u00FDmi onemocn\u011Bn\u00EDmi" . "P\u0159in\u00E1\u0161\u00ED d\u016Fle\u017Eit\u00E9 d\u00EDl\u010D\u00ED \u00FAdaje o etiologick\u00FDch faktorech n\u00E1dor\u016F prsu a kolorekta."@cs . " gene" . . . "0"^^ . " mutation" . " germline" . "2011-04-27+02:00"^^ . . "1"^^ . "1"^^ . "It brings important pieces of information about etiological factors and colorectal cancer tumors."@en . . "4"^^ . "NR9092" . "4"^^ . . . . "Bude p\u00E1tr\u00E1no po z\u00E1rode\u010Dn\u00FDch mutac\u00EDch genu PML u pacient\u016F s n\u00E1dory prsu a kolorekta, u nich\u017E je podez\u0159en\u00ED, \u017Ee onemocn\u011Bn\u00ED mohlo vzniknout na podklad\u011B heredit\u00E1rn\u00ED predispozice. Bude stanovena amplifikace genu pro cyklin D1 a ZNF217 ve vzorc\u00EDch n\u00E1dor\u016F prsu na podklad\u011B heredit\u00E1rn\u00ED predispozice a sporadick\u00FDch a p\u00E1tr\u00E1no po rozd\u00EDlech mezi ob\u011Bma skupinami n\u00E1dor\u016F." . "Mutational analysis of PML gene will be performed in patients with breast and colon cancer with suspect hereditary predisposition to cancer. Cyclin D1 and ZNF217 gene amplification analysis will be performed in breast cancer samples associated with hereditary predisposition and sporadic ones and differences between both groups will be determined."@en . .