"2006-01-01+01:00"^^ . . "7"^^ . "The detection of RUNX1 a CEBPA genes mutations was established and 5 novel mutations of RUNX1 gene coding region and 36 novel mutations of CEBPA gene were found. EVI1 mRNA level increasing in the course of MDS is the negative prognostic factor."@en . . "7"^^ . . "Genomic DNA of members of family with markers of familial platelet disorder with predisposition to acute myeloid leukemia will be examined for mutation in RUNX1 gene. Mutations in genes for transcription factor RUNX1 in AML and MDS patients and transcription factor CEBPA in AML patients will be analysed. The elevated level of transcription factor EVI1 mRNA is unfavorable prognostic marker for patients with AML and MDS. We will quantify EVI1 mRNA level."@en . "NR9045" . "acute myeloid leukemia; myelodysplastic syndrome; inherited thrombocytopenia; mutations detection; RUNX1; CEBPA; EVI1; quantitative PCR"@en . "\u00DAloha gen\u016F RUNX1, EVI1 a CEBPA p\u0159i patogenezi leuk\u00E9mi\u00ED a preleuk\u00E9mi\u00ED" . . "acute myeloid leukemia" . . " RUNX1" . "2011-04-27+02:00"^^ . " CEBPA" . . . "2008-12-31+01:00"^^ . . " myelodysplastic syndrome" . . "2008-03-05+01:00"^^ . . . . "0"^^ . "The role of RUNX1, EVI1 and CEBPA genes in the pathogenesis of leukemias and pre-leukemias"@en . . . "1"^^ . . " inherited thrombocytopenia" . . " EVI1" . " mutations detection" . "0"^^ . "Mutace v genu RUNX1 budou hled\u00E1ny u genomov\u00E9 DNA \u010Dlen\u016F rodiny se znaky d\u011Bdi\u010Dn\u00E9 poruchy desti\u010Dek s predispozic\u00ED k akutn\u00ED myeloidn\u00ED leuk\u00E9mii. Budou analyzov\u00E1ny mutace v genech pro transkrip\u010Dn\u00ED faktor RUNX1 u pacient\u016F s AML a MDS a transkrip\u010Dn\u00ED faktor CEBPA u pacient\u016F s AML. Zv\u00FD\u0161en\u00E1 hladina mRNA pro transkrip\u010Dn\u00ED faktor EVI1 je nep\u0159\u00EDzniv\u00FDm prognostick\u00FDm znakem pro pacienty s AML a MDS. Stanov\u00EDme hladinu mRNA pro EVI1." . . "Byla zavedena detekce mutac\u00ED genu RUNX1 a CEBPA a prok\u00E1z\u00E1no 5 nov\u00FDch mutac\u00ED k\u00F3duj\u00EDc\u00ED oblasti genu RUNX1 a 36 nov\u00FDch mutac\u00ED genu CEBPA u hematologick\u00FDch malignot. Zv\u00FD\u0161en\u00ED ladiny EVI1 mRNA v pr\u016Fb\u011Bhu MDS onemocn\u011Bn\u00ED je negativn\u00EDm prognostick\u00FDm faktorem."@cs . "http://www.isvav.cz/projectDetail.do?rowId=NR9045"^^ . .