"Formation of metastases is in malignant tumors related to e.g. increased endothelial expression of E-selectin, or VCAM-1. It is unclear, if the these changes are to be described as localised endothelial activation, or generalised endothelial dysfunction The aium of the proposed project is to study endothelial activation/dysfunction in patients with various stages of breast cancer. Markers of endothelial function will be related to the outcome of patients, namely to generalisation of localised disease. Endothelial dysfunction will be studied using sonographic measurement of flow mediated vasodilation, endothelial activation will be evaluated using the determination of soluble E-selectin, VCAM-1, PAI-1 and von Willebrand factor. It is hypothesized that the evaluation of endothelial dysfunction in patients with localised breast cancer could help to assess the outcome of patients, especially the risk of generalisation of the disease."@en . . . . "Projekt je zam\u011B\u0159en na \u0159e\u0161en\u00ED ot\u00E1zky endoteli\u00E1ln\u00ED dysfunkce u pacientek s karcinomem prsu se snahou rozd\u011Blit tyto pacientky na rozd\u00EDln\u00E9 prognostick\u00E9 skupiny v z\u00E1vislosti na sledovan\u00FDch parametrech."@cs . "2008-12-31+01:00"^^ . . "1"^^ . "Endothelial dysfunction in breast cancer"@en . . "1"^^ . . " E-selectin" . . "2"^^ . "2"^^ . "0"^^ . . . "2006-01-01+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NR9020"^^ . . "Endotelov\u00E1 dysfunkce u karcinomu prsu" . . "Metastazov\u00E1n\u00ED a angiogenze jsou u malign\u00EDch n\u00E1dor\u016F spojeny s aktivac\u00ED endotelu (nap\u0159. zv\u00FD\u0161en\u00E1 exprese E-selektinu \u010Di VCAM-1). T.\u010D. nen\u00ED jasn\u00E9, zda jde u malign\u00EDch n\u00E1dor\u016F o lokalizovanou aktivaci endotelu, \u010Di o generalizovanou endotelovou dysfunkci. C\u00EDlem navrhovan\u00E9ho projektu je studovat u pacientek s r\u016Fzn\u00FDmi stadii karcinomu prsu aktivaci endotelu a endotelovou dysfunkci. Markery aktivace a funkce endotelu budou vzta\u017Eeny k progn\u00F3ze nemocn\u00FDch, zejm\u00E9na ke generalizaci lokalizovan\u00E9ho onemocn\u011Bn\u00ED. Endotelov\u00E1 dysfunkce bude studov\u00E1na pomoc\u00ED sonografick\u00E9ho m\u011B\u0159en\u00ED pr\u016Ftokem stimulovan\u00E9 vazodilatace (flow mediated vasodilation), aktivace endotelu bude sledov\u00E1na pomoc\u00ED m\u011B\u0159en\u00ED solubiln\u00EDho E-selektinu, VCAM-1, PAI-1 a von Willebrandova faktoru. V\u00FDstupem projektu by m\u011Blo b\u00FDt zji\u0161t\u011Bn\u00ED, zda by vy\u0161et\u0159en\u00ED endotelov\u00E9 dysfunkce mohlo ji\u017E v dob\u011B prim\u00E1rn\u00ED diagn\u00F3zy karcinomu prsu p\u0159isp\u011Bt k odhadu progn\u00F3zy pacientky a p\u0159edpokl\u00E1dan\u00E9ho rizika generalizace." . "2011-04-27+02:00"^^ . . . " von Willebrand factor" . . "2008-03-05+01:00"^^ . . "Breast cancer patiens had an early increase of AGEs followed by further increase of AGEs and elevation of AOPP in patients with progressive disease. As the clinical significance of these observations is currently uncertain futher studies are waranted"@en . . "breast cancer; endothelium; endothelial dysfunction; E-selectin; von Willebrand factor; flow mediated vasodilation"@en . " endothelium" . " endothelial dysfunction" . "NR9020" . "breast cancer" . .